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Tbio
CHST4
Carbohydrate sulfotransferase 4

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location. Th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338482
  • ENSP00000341206
  • ENSG00000140835
  • ENST00000539698
  • ENSP00000441204

Symbol
  • GST3
  • LSST
  • GlcNAc6ST2
  • HECGLCNAC6ST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.6
tissue
0.6
cellular component
0.55
gene perturbation
0.47
cell line
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
CHST6
Tbio
Family:  Enzyme
Novelty:  0.01917947
p_int:  0.999838688
p_wrong:  0.000161312
Score:  0.41
Data Source:  BioPlex,STRINGDB
MUC1
Tchem
Novelty:  0.00024203
Score:  0.913
Data Source:  STRINGDB
MUC4
Tbio
Novelty:  0.00193208
Score:  0.909
Data Source:  STRINGDB
MUC6
Tbio
Novelty:  0.00304872
Score:  0.904
Data Source:  STRINGDB
NTAN1
Tbio
Family:  Enzyme
Novelty:  0.01112132
Score:  0.904
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.903
Data Source:  STRINGDB
MUC3A
Tbio
Novelty:  0.0576775
Score:  0.903
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.902
Data Source:  STRINGDB
MUC17
Tbio
Novelty:  0.03624836
Score:  0.9
Data Source:  STRINGDB
MUCL1
Tbio
Novelty:  0.05915667
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
4
5
87.4
total cholesterol measurement
2
3
4
82.2
apolipoprotein B measurement
1
2
2
69.3
sex hormone-binding globulin measurement
3
2
3
38.8
pulse pressure measurement
1
1
1
37.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
87.4
total cholesterol measurement
4
82.2
apolipoprotein B measurement
2
69.3
sex hormone-binding globulin measurement
3
38.8
pulse pressure measurement
1
37.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 4
VGNC:9040
468019
Macaque
carbohydrate sulfotransferase 4
708116
Mouse
MGI:1349479
26887
Rat
RGD:1310798
307838
Dog
carbohydrate sulfotransferase 4
VGNC:39256
489722
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 4
Macaque
carbohydrate sulfotransferase 4
Mouse
Rat
Dog
carbohydrate sulfotransferase 4
Publication Statistics
PubMed Score 44.00
PubMed score by year
PubTator Score 24.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title