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Tclin
CHRNB2
Neuronal acetylcholine receptor subunit beta-2

Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368476
  • ENSP00000357461
  • ENSG00000160716

Symbol
  • EFNL3
  • nAChRB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.98
chemical
0.96
protein domain
0.85
biological term
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.93   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.93   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
Score:  0.981
Data Source:  STRINGDB
CHRNA4
Tclin
Family:  IC
Novelty:  0.00494934
Score:  0.966
Data Source:  Reactome,STRINGDB
CHRNA2
Tchem
Family:  IC
Novelty:  0.02542208
Score:  0.96
Data Source:  STRINGDB
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
Score:  0.956
Data Source:  Reactome,STRINGDB
CHRNA5
Tbio
Family:  IC
Novelty:  0.00425291
Score:  0.956
Data Source:  Reactome,STRINGDB
CHRNA7
Tchem
Family:  IC
Novelty:  0.00590784
Score:  0.937
Data Source:  STRINGDB
CHRNA6
Tchem
Family:  IC
Novelty:  0.03991261
Score:  0.932
Data Source:  STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
Score:  0.912
Data Source:  STRINGDB
CHRNB3
Tchem
Family:  IC
Novelty:  0.031456
Score:  0.911
Data Source:  STRINGDB
CHRNE
Tclin
Family:  IC
Novelty:  0.01908511
Score:  0.91
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Acetylcholine binding and downstream events (R-HSA-181431)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine binding and downstream events
Reactome
Highly calcium permeable nicotinic acetylcholine receptors
Reactome
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Reactome
Highly sodium permeable acetylcholine nicotinic receptors
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Acetylcholine binding and downstream events
Highly calcium permeable nicotinic acetylcholine receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly sodium permeable acetylcholine nicotinic receptors
Neuronal System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (67)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
DFLAT
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
10
10
98.5
sex hormone-binding globulin measurement
6
3
6
96
leukocyte count
1
1
1
70.2
apolipoprotein A 1 measurement
1
1
1
70
cigarettes per day measurement
2
1
2
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
10
98.5
sex hormone-binding globulin measurement
6
96
leukocyte count
1
70.2
apolipoprotein A 1 measurement
1
70
cigarettes per day measurement
2
65.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic beta 2 subunit
VGNC:10570
740303
Macaque
cholinergic receptor nicotinic beta 2 subunit
716830
Mouse
MGI:87891
11444
Rat
RGD:2350
54239
Dog
cholinergic receptor nicotinic beta 2 subunit
VGNC:39243
490443
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic beta 2 subunit
Macaque
cholinergic receptor nicotinic beta 2 subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic beta 2 subunit
Publication Statistics
PubMed Score 74.93
PubMed score by year
PubTator Score 41.48
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title