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Tclin
CHRNB1
Acetylcholine receptor subunit beta

Protein Summary
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306071
  • ENSP00000304290
  • ENSG00000170175
  • ENST00000536404
  • ENSP00000439209
  • ENST00000639692
  • ENSP00000492221
  • ENSG00000283946
  • ENST00000639993
  • ENSP00000491113

Symbol
  • ACHRB
  • CHRNB
  • ACHRB
  • CHRNB
  • CMS1D
  • CMS2A
  • CMS2C
  • SCCMS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.85
gene perturbation
0.83
small molecule perturbation
0.65
disease perturbation
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.81   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.81   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (13)
tubocurarine
Rendered image for tubocurarine
decamethonium
Rendered image for decamethonium
suxamethonium
Rendered image for suxamethonium
rapacuronium
Rendered image for rapacuronium
atracurium
Rendered image for atracurium
cisatracurium
Rendered image for cisatracurium
dimethyltubocurarinium
Rendered image for dimethyltubocurarinium
mivacurium
Rendered image for mivacurium
pancuronium
Rendered image for pancuronium
pipecuronium
Rendered image for pipecuronium
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
AGTRAP
Tbio
Novelty:  0.02295361
p_int:  0.999999465
p_ni:  5.03e-7
p_wrong:  3.3e-8
Data Source:  BioPlex
VWA1
Tbio
Novelty:  0.00212445
p_int:  0.99936728
p_ni:  0.000606336
p_wrong:  0.000026384
Score:  0.156
Data Source:  BioPlex,STRINGDB
C1orf43
Tbio
Novelty:  0.13587458
p_int:  0.998908546
p_ni:  0.001091453
p_wrong:  1e-9
Data Source:  BioPlex
SARAF
Tbio
Novelty:  0.0383833
p_int:  0.997551544
p_ni:  0.002445108
p_wrong:  0.000003348
Data Source:  BioPlex
DNAJC30
Tdark
Novelty:  0.57178901
p_int:  0.996628278
p_ni:  0.003226537
p_wrong:  0.000145185
Data Source:  BioPlex
MFAP3
Tdark
Novelty:  0.55512255
p_int:  0.988593897
p_ni:  0.011404184
p_wrong:  0.000001919
Data Source:  BioPlex
GHDC
Tbio
Novelty:  0.08423152
p_int:  0.981088806
p_ni:  0.018911192
p_wrong:  2e-9
Data Source:  BioPlex
PCNX3
Tdark
Novelty:  0.76597717
p_int:  0.975529105
p_ni:  0.024443298
p_wrong:  0.000027597
Data Source:  BioPlex
LEMD2
Tbio
Novelty:  0.12460123
p_int:  0.975287487
p_ni:  0.024712513
Data Source:  BioPlex
LRP12
Tbio
Novelty:  0.11426952
p_int:  0.974580099
p_ni:  0.024675448
p_wrong:  0.000744453
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SynGO
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (70)
Items per page:
1 – 5 of 70
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
16
17
99.6
testosterone measurement
2
16
17
99.6
serum non-albumin protein measurement
2
5
5
98
serum non-albumin protein measurement
2
5
5
98
blood protein measurement
1
3
3
88.8
Items per page:
1 – 5 of 70
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
17
99.6
testosterone measurement
17
99.6
serum non-albumin protein measurement
5
98
serum non-albumin protein measurement
5
98
blood protein measurement
3
88.8
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic beta 1 subunit
VGNC:9235
454461
Macaque
cholinergic receptor nicotinic beta 1 subunit
715509
Mouse
MGI:87890
11443
Rat
RGD:2349
24261
Dog
cholinergic receptor nicotinic beta 1 subunit
VGNC:39242
489473
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholinergic receptor nicotinic beta 1 subunit
Macaque
cholinergic receptor nicotinic beta 1 subunit
Mouse
Rat
Dog
cholinergic receptor nicotinic beta 1 subunit
Publication Statistics
PubMed Score 18.81
PubMed score by year
PubTator Score 30.65
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title