CHRNA7
Neuronal acetylcholine receptor subunit alpha-7
Protein Summary
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it un ...more
- ENST00000306901
- ENSP00000303727
- ENSG00000175344
- ENST00000437966
- ENSP00000399087
- ENST00000454250
- ENSP00000407546
- NACHRA7
- NACHRA7
- CHRNA7-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 181.73 (req: < 5)
Gene RIFs: 215 (req: <= 3)
Antibodies: 288 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 181.73 (req: >= 5)
Gene RIFs: 215 (req: > 3)
Antibodies: 288 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 47
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 787
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 11
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (11)
Active Ligands (787)
Protein-Protein Interactions (79)
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (17)
Reactome (6)
KEGG (5)
PathwayCommons (3)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acetylcholine binding and downstream events | ||||
Reactome | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter receptors and postsynaptic signal transmission | ||||
Reactome | Postsynaptic nicotinic acetylcholine receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acetylcholine binding and downstream events | ||||
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
Neuronal System | ||||
Neurotransmitter receptors and postsynaptic signal transmission | ||||
Postsynaptic nicotinic acetylcholine receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (57)
Functions (9)
Components (10)
Processes (38)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | ARUK-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | ARUK-UCL | |||
Disease Associations (null)
GWAS Traits (0)
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IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cholinergic receptor nicotinic alpha 7 subunit | 467639 | ||||||
Macaque | cholinergic receptor nicotinic alpha 7 subunit | 574230 | ||||||
Mouse | MGI:99779 | 11441 | ||||||
Rat | RGD:2348 | 25302 | ||||||
Dog | cholinergic receptor nicotinic alpha 7 subunit | 488696 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cholinergic receptor nicotinic alpha 7 subunit | |||||
Macaque | cholinergic receptor nicotinic alpha 7 subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | cholinergic receptor nicotinic alpha 7 subunit | |||||
Publication Statistics
PubMed Score 181.73
PubMed score by year
PubTator Score 278.27
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (270)
GeneRif Annotations (215)
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