CHRNA6
Neuronal acetylcholine receptor subunit alpha-6
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.85 | ||
molecular function | 0.84 | ||
cell line | 0.62 | ||
transcription factor perturbation | 0.54 | ||
small molecule perturbation | 0.52 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Acetylcholine binding and downstream events | ||||
Reactome | Highly calcium permeable nicotinic acetylcholine receptors | ||||
Reactome | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter receptors and postsynaptic signal transmission | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Acetylcholine binding and downstream events | ||||
Highly calcium permeable nicotinic acetylcholine receptors | ||||
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
Neuronal System | ||||
Neurotransmitter receptors and postsynaptic signal transmission | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
cigarettes per day measurement | 3 | 3 | 3 | 91.7 | |||||
1 | 1 | 1 | 33.1 | ||||||
tobacco smoke exposure measurement | 1 | 1 | 1 | 21.5 | |||||
smoking cessation | 2 | 1 | 2 | 12.8 | |||||
smoking behavior | 1 | 1 | 1 | 4.6 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
cigarettes per day measurement | 3 | 91.7 | |||||
1 | 33.1 | ||||||
tobacco smoke exposure measurement | 1 | 21.5 | |||||
smoking cessation | 2 | 12.8 | |||||
smoking behavior | 1 | 4.6 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cholinergic receptor nicotinic alpha 6 subunit | VGNC:7591 | 472750 | |||||
Macaque | cholinergic receptor nicotinic alpha 6 subunit | 705725 | ||||||
Mouse | MGI:106213 | 11440 | ||||||
Rat | RGD:69281 | 81721 | ||||||
Dog | cholinergic receptor nicotinic alpha 6 subunit | VGNC:39240 | 482836 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cholinergic receptor nicotinic alpha 6 subunit | |||||
Macaque | cholinergic receptor nicotinic alpha 6 subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | cholinergic receptor nicotinic alpha 6 subunit | |||||
PMID | Year | Title |
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