CHRNA6
Neuronal acetylcholine receptor subunit alpha-6
Protein Summary
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]
- ENST00000276410
- ENSP00000276410
- ENSG00000147434
- ENST00000534622
- ENSP00000433871
- CHNRA6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
molecular function | 0.84 | ||
cell line | 0.62 | ||
transcription factor perturbation | 0.54 | ||
small molecule perturbation | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.87 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 134 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.87 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 134 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (1)
Protein-Protein Interactions (53)
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (14)
Reactome (8)
KEGG (3)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acetylcholine binding and downstream events | ||||
Reactome | Highly calcium permeable nicotinic acetylcholine receptors | ||||
Reactome | Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter receptors and postsynaptic signal transmission | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acetylcholine binding and downstream events | ||||
Highly calcium permeable nicotinic acetylcholine receptors | ||||
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | ||||
Neuronal System | ||||
Neurotransmitter receptors and postsynaptic signal transmission | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (2)
Components (9)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cigarettes per day measurement | 3 | 3 | 3 | 91.7 | |||||
1 | 1 | 1 | 33.1 | ||||||
tobacco smoke exposure measurement | 1 | 1 | 1 | 21.5 | |||||
smoking cessation | 2 | 1 | 2 | 12.8 | |||||
smoking behavior | 1 | 1 | 1 | 4.6 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cigarettes per day measurement | 3 | 91.7 | |||||
1 | 33.1 | ||||||
tobacco smoke exposure measurement | 1 | 21.5 | |||||
smoking cessation | 2 | 12.8 | |||||
smoking behavior | 1 | 4.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cholinergic receptor nicotinic alpha 6 subunit | VGNC:7591 | 472750 | |||||
Macaque | cholinergic receptor nicotinic alpha 6 subunit | 705725 | ||||||
Mouse | MGI:106213 | 11440 | ||||||
Rat | RGD:69281 | 81721 | ||||||
Dog | cholinergic receptor nicotinic alpha 6 subunit | VGNC:39240 | 482836 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cholinergic receptor nicotinic alpha 6 subunit | |||||
Macaque | cholinergic receptor nicotinic alpha 6 subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | cholinergic receptor nicotinic alpha 6 subunit | |||||
Publication Statistics
PubMed Score 23.87
PubMed score by year
PubTator Score 13.42
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (53)
GeneRif Annotations (32)
Items per page:
0 of 0
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