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Tclin
CHRM4
Muscarinic acetylcholine receptor M4

Protein Summary
Description
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433765
  • ENSP00000409378
  • ENSG00000180720

Symbol
  • HM4
  • M4R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
drug
0.99
chemical
0.7
pathway
0.64
biological process
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.58   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.58   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 356
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 48
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (48)
clozapine
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chlorpromazine
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olanzapine
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amitriptyline
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thioridazine
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clemastine
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cyproheptadine
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clomipramine
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nortriptyline
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promazine
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Active Ligands (356)
staurosporine
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xanomeline
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dosulepin
Rendered image for dosulepin
(S)-dimetindene
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Valethamate Bromide
Rendered image for Valethamate Bromide
Cetylpyridinium Bromide
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Benzethonium Chloride
Rendered image for Benzethonium Chloride
oxotremorine
Rendered image for oxotremorine
CHEMBL3629360
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Protein-Protein Interactions (304)
USP24
Tbio
Family:  Enzyme
Novelty:  0.07281326
p_int:  0.998965712
p_ni:  0.001034288
Data Source:  BioPlex
PDS5B
Tbio
Novelty:  0.00295057
p_int:  0.998792786
p_ni:  0.001207195
p_wrong:  2e-8
Data Source:  BioPlex
PPP1R15B
Tchem
Family:  Enzyme
Novelty:  0.0244819
p_int:  0.994952074
p_ni:  0.005047923
p_wrong:  3e-9
Data Source:  BioPlex
GSPT1
Tbio
Family:  Enzyme
Novelty:  0.02545195
p_int:  0.993456205
p_ni:  0.006543795
Score:  0.179
Data Source:  BioPlex,STRINGDB
PDXDC1
Tbio
Family:  Enzyme
Novelty:  0.16529476
p_int:  0.991589567
p_ni:  0.008410433
Data Source:  BioPlex
CAND2
Tbio
Novelty:  0.08940552
p_int:  0.988028297
p_ni:  0.011971703
Data Source:  BioPlex
XPO6
Tbio
Novelty:  0.03229708
p_int:  0.985416154
p_ni:  0.014583844
p_wrong:  3e-9
Data Source:  BioPlex
LPCAT3
Tbio
Family:  Enzyme
Novelty:  0.00485213
p_int:  0.985244096
p_ni:  0.014755898
p_wrong:  6e-9
Data Source:  BioPlex
THADA
Tbio
Novelty:  0.06983966
p_int:  0.976791012
p_ni:  0.023208988
Data Source:  BioPlex
IPO9
Tbio
Novelty:  0.03978028
p_int:  0.976368084
p_ni:  0.023631916
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Amine ligand-binding receptors (R-HSA-375280)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
2
2
75
bone density
1
2
3
71.1
3
2
1
1.1
69.6
high density lipoprotein cholesterol measurement
1
1
1
67.3
smoking status measurement
2
2
2
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
75
bone density
3
71.1
1
1.1
69.6
high density lipoprotein cholesterol measurement
1
67.3
smoking status measurement
2
66.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88399
12672
Rat
RGD:2344
25111
Dog
cholinergic receptor muscarinic 4
VGNC:39234
611314
Chicken
cholinergic receptor muscarinic 4
CGNC:6339
423195
Anole lizard
cholinergic receptor muscarinic 4
100553418
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cholinergic receptor muscarinic 4
Chicken
cholinergic receptor muscarinic 4
Anole lizard
cholinergic receptor muscarinic 4
Publication Statistics
PubMed Score 133.58
PubMed score by year
PubTator Score 40.53
PubTator score by year
Patents
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Related Publications
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PMID
Year
Title