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Tbio
CHRDL1
Chordin-like protein 1

Protein Summary
Description
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development. This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372042
  • ENSP00000361112
  • ENSG00000101938
  • ENST00000372045
  • ENSP00000361115
  • ENST00000394797
  • ENSP00000378276
  • ENST00000444321
  • ENSP00000399739
  • ENST00000482160
  • ENSP00000418443

Symbol
  • NRLN1
  • CHL
  • MGC1
  • MGCN
  • VOPT
  • NRLN1
  • dA141H5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.63
gene perturbation
0.61
PubMedID
0.58
microRNA
0.57
small molecule perturbation
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.43   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.43   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
CALCOCO2
Tbio
Novelty:  0.01456844
p_int:  0.999931743
p_ni:  0.000068257
Score:  0.189
Data Source:  BioPlex,STRINGDB
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.999581519
p_ni:  0.000418381
p_wrong:  9.9e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.998797992
p_ni:  0.001202005
p_wrong:  3e-9
Data Source:  BioPlex
HECTD3
Tdark
Family:  Enzyme
Novelty:  2.20874654
p_int:  0.997496223
p_ni:  0.002503777
Score:  0.183
Data Source:  BioPlex,STRINGDB
LRP1B
Tbio
Novelty:  0.01443405
p_int:  0.955551392
p_ni:  0.044448608
Score:  0.213
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.915116276
p_ni:  0.084745009
p_wrong:  0.000138715
Data Source:  BioPlex
BMP4
Tchem
Novelty:  0.00047387
Score:  0.976
Data Source:  STRINGDB
FSTL1
Tbio
Novelty:  0.00557848
Score:  0.957
Data Source:  STRINGDB
BMPR1B
Tchem
Family:  Kinase
Novelty:  0.00698763
Score:  0.951
Data Source:  STRINGDB
BMP2
Tbio
Novelty:  0.00016974
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
3
3
89.7
sex hormone-binding globulin measurement
5
2
6
53.7
platelet crit
1
1
1
17.2
platelet count
1
1
1
15.8
hemoglobin measurement
1
1
1
14.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
89.7
sex hormone-binding globulin measurement
6
53.7
platelet crit
1
17.2
platelet count
1
15.8
hemoglobin measurement
1
14.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chordin like 1
740739
Macaque
chordin like 1
706100
Mouse
MGI:1933172
83453
Rat
RGD:735215
363455
Dog
chordin like 1
VGNC:39229
492066
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chordin like 1
Macaque
chordin like 1
Mouse
Rat
Dog
chordin like 1
Publication Statistics
PubMed Score 64.43
PubMed score by year
PubTator Score 99.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title