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Tbio
CHRD
Chordin

Protein Summary
Description
Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity). This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000204604
  • ENSP00000204604
  • ENSG00000090539
  • ENST00000348986
  • ENSP00000334036
  • ENST00000356534
  • ENSP00000348930
  • ENST00000420973
  • ENSP00000392794
  • ENST00000448472
  • ENSP00000408624
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
cell type or tissue
0.73
PubMedID
0.71
phenotype
0.7
biological process
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.63   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 296.63   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
BMP2
Tbio
Novelty:  0.00016974
Score:  0.998
Data Source:  STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.994
Data Source:  STRINGDB
BAMBI
Tbio
Novelty:  0.00736806
Score:  0.966
Data Source:  STRINGDB
BMPR1A
Tchem
Family:  Kinase
Novelty:  0.00343928
Score:  0.965
Data Source:  STRINGDB
BMPR1B
Tchem
Family:  Kinase
Novelty:  0.00698763
Score:  0.964
Data Source:  STRINGDB
BMPR2
Tchem
Family:  Kinase
Novelty:  0.00155912
Score:  0.959
Data Source:  STRINGDB
TLL1
Tchem
Novelty:  0.02261325
Score:  0.952
Data Source:  STRINGDB
NKX2-5
Tbio
Family:  TF
Novelty:  0.00125993
Score:  0.936
Data Source:  STRINGDB
BMP7
Tbio
Novelty:  0.00049424
Score:  0.929
Data Source:  STRINGDB
RGMB
Tbio
Novelty:  0.05317349
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
8
9
17
7.5
98.9
appendicular lean mass
4
2
4
93.2
platelet crit
2
9
12
92.2
hematological measurement
1
1
1
90.7
age at menarche
1
1
1
68.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
17
7.5
98.9
appendicular lean mass
4
93.2
platelet crit
12
92.2
hematological measurement
1
90.7
age at menarche
1
68.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chordin
VGNC:1777
460892
Macaque
chordin
702281
Mouse
MGI:1313268
12667
Rat
RGD:620181
117275
Dog
chordin
VGNC:39228
607289
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chordin
Macaque
chordin
Mouse
Rat
Dog
chordin
Publication Statistics
PubMed Score 296.63
PubMed score by year
PubTator Score 63.57
PubTator score by year
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Related Publications
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PMID
Year
Title