Tbio CHPF2 Chondroitin sulfate glucuronyltransferase

Protein Summary

Description

Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.

Uniprot Accession IDs

• Q9P2E5
• B2DBD8
• Q6P2I4
• Q6UXD2

Gene Name

• CHPF2

Ensembl ID

• ENST00000035307
• ENSP00000035307
• ENSG00000033100

Symbol

• CHSY3
• CSGLCAT
• KIAA1402
• ChSy-3
• chPF-2
• CSGlcAT
• CSGLCA-T

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.92
transcription factor perturbation	0.8
kinase perturbation	0.76
transcription factor binding site profile	0.69
cell type or tissue	0.66

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Chondroitin Sulfate Glucuronyltransferase

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Chondroitin Sulfate Glucuronyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.55   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.55   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0