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Tbio
CHP1
Calcineurin B homologous protein 1

Protein Summary
Description
Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334660
  • ENSP00000335632
  • ENSG00000187446

Symbol
  • CHP
  • CHP
  • p22
  • p24
  • Sid470p
  • SLC9A1BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
interacting protein
0.95
transcription factor perturbation
0.88
small molecule perturbation
0.86
transcription factor binding site profile
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.51   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.51   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
COG4
Tbio
Novelty:  0.03809668
p_int:  0.776314337
p_ni:  0.223685663
Data Source:  BioPlex
SLC9A1
Tchem
Family:  Transporter
Novelty:  0.00096678
Score:  0.998
Data Source:  Reactome,STRINGDB
SLC9A3
Tclin
Family:  Transporter
Novelty:  0.00146466
Score:  0.912
Data Source:  STRINGDB
STAB2
Tbio
Novelty:  0.01141869
Score:  0.902
Data Source:  Reactome,STRINGDB
CD44
Tbio
Novelty:  0.00011321
Score:  0.9
Data Source:  Reactome,STRINGDB
LYVE1
Tbio
Novelty:  0.00186825
Score:  0.9
Data Source:  Reactome,STRINGDB
HYAL2
Tbio
Family:  Enzyme
Novelty:  0.00740331
Score:  0.9
Data Source:  Reactome,STRINGDB
HMMR
Tchem
Novelty:  0.0039196
Score:  0.9
Data Source:  Reactome,STRINGDB
CHORDC1
Tbio
Novelty:  0.03400277
Score:  0.89
Data Source:  STRINGDB
SLC9A2
Tchem
Family:  Transporter
Novelty:  0.00687506
Score:  0.882
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (55)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
Hyaluronan metabolism
Reactome
Hyaluronan uptake and degradation
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
Hyaluronan metabolism
Hyaluronan uptake and degradation
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (45)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
0
7.4
59
hematocrit
1
1
1
51.7
leukocyte count
1
1
1
46.5
lifestyle measurement
1
1
1
31.4
cognitive function measurement
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
0
7.4
59
hematocrit
1
51.7
leukocyte count
1
46.5
lifestyle measurement
1
31.4
cognitive function measurement
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcineurin like EF-hand protein 1
VGNC:7203
467662
Macaque
calcineurin like EF-hand protein 1
705482
Mouse
MGI:1927185
56398
Rat
RGD:620447
64152
Dog
calcineurin like EF-hand protein 1
VGNC:39227
478264
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcineurin like EF-hand protein 1
Macaque
calcineurin like EF-hand protein 1
Mouse
Rat
Dog
calcineurin like EF-hand protein 1
Publication Statistics
PubMed Score 72.51
PubMed score by year
PubTator Score 650.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title