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Tbio
CHMP5
Charged multivesicular body protein 5

Protein Summary
Description
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223500
  • ENSP00000223500
  • ENSG00000086065
  • ENST00000419016
  • ENSP00000442725

Symbol
  • C9orf83
  • SNF7DC2
  • Vps60
  • CGI-34
  • PNAS-2
  • C9orf83
  • HSPC177
  • SNF7DC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
histone modification site profile
0.87
cell type or tissue
0.8
transcription factor binding site profile
0.78
interacting protein
0.75


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.63   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.63   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
VTA1
Tbio
Novelty:  0.01697854
p_int:  0.999999994
p_ni:  6e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999996123
p_ni:  5.2e-8
p_wrong:  0.000003825
Score:  0.258
Data Source:  BioPlex,STRINGDB
STMN4
Tbio
Novelty:  0.00422625
p_int:  0.999731209
p_ni:  2.4e-7
p_wrong:  0.00026855
Score:  0.798
Data Source:  BioPlex,STRINGDB
CHMP1A
Tbio
Novelty:  0.03969333
p_int:  0.99791663
p_ni:  0.002083271
p_wrong:  1e-7
Score:  0.956
Data Source:  BioPlex,STRINGDB
CHMP3
Tbio
Novelty:  0.01958573
p_int:  0.98949588
p_ni:  0.010503826
p_wrong:  2.94e-7
Score:  0.944
Data Source:  BioPlex,STRINGDB
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  0.98077149
p_ni:  0.01922851
Score:  0.522
Data Source:  BioPlex,STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
p_int:  0.953081705
p_ni:  0.046918295
Score:  0.998
Data Source:  BioPlex,STRINGDB
VPS4B
Tchem
Novelty:  0.00788708
Score:  0.994
Data Source:  Reactome,STRINGDB
CHMP6
Tbio
Novelty:  0.02931
Score:  0.992
Data Source:  STRINGDB
CHMP4C
Tbio
Novelty:  0.07423155
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Budding and maturation of HIV virion (R-HSA-162588)

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Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Reactome
HIV Infection
Reactome
HIV Life Cycle
Name
Explore in Pharos
Explore in Source
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
HIV Infection
HIV Life Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
1
2
78.3
influenza A (H1N1)
3
1
0
21.1
62.1
glomerular filtration rate
1
1
1
33.1
glucose measurement
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
78.3
influenza A (H1N1)
0
21.1
62.1
glomerular filtration rate
1
33.1
glucose measurement
1
6.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
charged multivesicular body protein 5
VGNC:4662
746713
Macaque
charged multivesicular body protein 5
703191
Mouse
MGI:1924209
76959
Rat
RGD:1305968
297995
Dog
charged multivesicular body protein 5
474741
Species
Name
OMA
EggNOG
Inparanoid
Chimp
charged multivesicular body protein 5
Macaque
charged multivesicular body protein 5
Mouse
Rat
Dog
charged multivesicular body protein 5
Publication Statistics
PubMed Score 31.63
PubMed score by year
PubTator Score 15.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title