CHMP4C
Charged multivesicular body protein 4c
Protein Summary
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature r ...more
- ENST00000297265
- ENSP00000297265
- ENSG00000164695
- SHAX3
- Shax3
- SNF7-3
- VPS32C
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.77 | ||
gene perturbation | 0.76 | ||
biological process | 0.64 | ||
cellular component | 0.62 | ||
transcription factor perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.48 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 62 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 17.48 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 62 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (81)
Nearest Tclin Targets
Pathways (15)
Reactome (13)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Autophagy | ||||
Reactome | Budding and maturation of HIV virion | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Disease | ||||
Reactome | Endosomal Sorting Complex Required For Transport (ESCRT) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Autophagy | ||||
Budding and maturation of HIV virion | ||||
Cellular responses to external stimuli | ||||
Disease | ||||
Endosomal Sorting Complex Required For Transport (ESCRT) | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (1)
Components (5)
Processes (18)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hair color | 2 | 2 | 0 | 1.1 | 86.8 | ||||
1 | 1 | 0 | 1.2 | 37.6 | |||||
age-related hearing impairment | 1 | 1 | 0 | 5.6 | 21.5 | ||||
mean platelet volume | 1 | 1 | 1 | 12.3 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hair color | 0 | 1.1 | 86.8 | ||||
0 | 1.2 | 37.6 | |||||
age-related hearing impairment | 0 | 5.6 | 21.5 | ||||
mean platelet volume | 1 | 12.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | charged multivesicular body protein 4C | VGNC:914 | 472807 | |||||
Macaque | charged multivesicular body protein 4C | 702310 | ||||||
Mouse | MGI:1913621 | 66371 | ||||||
Rat | RGD:1564543 | 361916 | ||||||
Dog | charged multivesicular body protein 4C | VGNC:39224 | 477926 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | charged multivesicular body protein 4C | |||||
Macaque | charged multivesicular body protein 4C | |||||
Mouse | ||||||
Rat | ||||||
Dog | charged multivesicular body protein 4C | |||||
Publication Statistics
PubMed Score 17.48
PubMed score by year
PubTator Score 10.68
PubTator score by year
Related Publications
Text Mined References (28)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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