Tbio CHMP4B Charged multivesicular body protein 4b

Protein Summary

Description

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). (Microbial infection) The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9H444
• E1P5N4
• Q53ZD6

Gene Name

• CHMP4B

Ensembl ID

• ENST00000217402
• ENSP00000217402
• ENSG00000101421

Symbol

• C20orf178
• SHAX1
• SNF7
• CTPP3
• Shax1
• CHMP4A
• SNF7-2
• VPS32B
• CTRCT31
• Vps32-2
• C20orf178
• dJ553F4.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
biological process	0.91
interacting protein	0.9
virus perturbation	0.83
transcription factor binding site profile	0.79

Protein Classes

PANTHER Classes

Protein / Transfer/carrier Protein / Charged Multivesicular Body Protein 4b

DTO Classes

Protein / Transporter / Charged Multivesicular Body Protein 4b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.18   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 162   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.18   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (137)

Explore Interacting Targets

1 – 10 of 137

• See Interactions on String-DB

CHMP2A

Tbio

Novelty:  0.00169253

Score:  0.999

Data Source:  STRINGDB

CHMP3

Tbio

Novelty:  0.01958573

Score:  0.999

Data Source:  STRINGDB

CHMP1B

Tbio

Novelty:  0.06982523

Score:  0.999

Data Source:  STRINGDB

PDCD6IP

Tbio

Novelty:  0.01836118

Score:  0.995

Data Source:  STRINGDB

VPS25

Tbio

Novelty:  0.03002488

Score:  0.994

Data Source:  STRINGDB

VPS4A

Tbio

Novelty:  0.01508121

Score:  0.994

Data Source:  STRINGDB

TSG101

Tbio

Novelty:  0.00211746

Score:  0.992

Data Source:  STRINGDB

VPS4B

Tchem

Novelty:  0.00788708

Score:  0.992

Data Source:  STRINGDB

SNF8

Tbio

Novelty:  0.04841708

Score:  0.991

Data Source:  STRINGDB

VPS36

Tbio

Novelty:  0.03382542

Score:  0.991

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (15)

Reactome (13)

KEGG (2)

Autophagy (R-HSA-9612973)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Autophagy	109 targets	R-HSA-9612973
Reactome	Budding and maturation of HIV virion	28 targets	R-HSA-162588
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Endosomal Sorting Complex Required For Transport (ESCRT)	31 targets	R-HSA-917729

Name	Explore in Pharos	Explore in Source
Autophagy	109 targets	R-HSA-9612973
Budding and maturation of HIV virion	28 targets	R-HSA-162588
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Disease	1105 targets	R-HSA-1643685
Endosomal Sorting Complex Required For Transport (ESCRT)	31 targets	R-HSA-917729

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (41)

Functions (3)

Components (12)

Processes (26)

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1 – 3 of 3

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Direct Assay (IDA)	UniProtKB
protein homodimerization activity	Inferred from Physical Interaction (IPI)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL

Disease Associations ()

No disease associations found

GWAS Traits (12)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	2	2	2		91.5
suntan	EFO_0004279	1	1	1		88.2
BMI-adjusted hip circumference	EFO_0008039	2	6	6		84.9
non-melanoma skin carcinoma	EFO_0009260	1	2	0	1.3	68
anthropometric measurement	EFO_0004302	1	1	0	1.2	62.1

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	2		91.5
suntan	EFO_0004279	1		88.2
BMI-adjusted hip circumference	EFO_0008039	6		84.9
non-melanoma skin carcinoma	EFO_0009260	0	1.3	68
anthropometric measurement	EFO_0004302	0	1.2	62.1

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Cataract
Coiled coil
Complete proteome
Cytoplasm
Direct protein sequencing
Disease mutation
Endosome
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
anthropometric measurement
appendicular lean mass
birth weight
BMI-adjusted hip circumference
body height
HbA1c measurement
melanoma
non-melanoma skin carcinoma
parental genotype effect measurement
squamous cell carcinoma

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	charged multivesicular body protein 4B	VGNC:6080	747134
Macaque	charged multivesicular body protein 4B		709004
Mouse	charged multivesicular body protein 4B	MGI:1922858	75608
Rat	chromatin modifying protein 4B-like 1	RGD:1583604	679886
Dog	charged multivesicular body protein 4B	VGNC:54643	485842

Species	Name	OMA	EggNOG	Inparanoid
Chimp	charged multivesicular body protein 4B
Macaque	charged multivesicular body protein 4B
Mouse	charged multivesicular body protein 4B
Rat	chromatin modifying protein 4B-like 1
Dog	charged multivesicular body protein 4B

Publication Statistics

PubMed Score 75.18

PubMed score by year

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PubTator Score 22.65

PubTator score by year

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Related Publications

Text Mined References (56)

GeneRif Annotations (17)

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PMID	Year	Title