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Tbio
CHMP4A
Charged multivesicular body protein 4a

Protein Summary
Description
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347519
  • ENSP00000324205
  • ENSG00000254505
  • ENST00000609024
  • ENSP00000476412
  • ENST00000645179
  • ENSP00000495781
  • ENSG00000285302
  • ENST00000645308
  • ENSP00000495982

Symbol
  • C14orf123
  • SHAX2
  • SNF7
  • CHMP4
  • SHAX2
  • CHMP4B
  • SNF7-1
  • VPS32A
  • HSPC134
  • VPS32-1
  • C14orf123
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.88
biological process
0.8
tissue sample
0.64
cell type or tissue
0.63
histone modification site profile
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.56   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.56   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0