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Tbio
CHMP2A
Charged multivesicular body protein 2a

Protein Summary
Description
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312547
  • ENSP00000310440
  • ENSG00000130724
  • ENST00000600118
  • ENSP00000469240
  • ENST00000601220
  • ENSP00000472680

Symbol
  • BC2
  • CHMP2
  • BC2
  • BC-2
  • VPS2
  • CHMP2
  • VPS2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
disease perturbation
0.95
kinase perturbation
0.93
biological process
0.8
transcription factor binding site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 612.36   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 612.36   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
TRIM35
Tbio
Novelty:  0.03280419
p_int:  0.99999577
p_ni:  0.000004174
p_wrong:  5.6e-8
Score:  0.201
Data Source:  BioPlex,STRINGDB
VTA1
Tbio
Novelty:  0.01697854
p_int:  0.999863822
p_ni:  0.000136178
Score:  0.997
Data Source:  BioPlex,STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
p_int:  0.962858147
p_ni:  0.037141853
Score:  0.209
Data Source:  BioPlex,STRINGDB
MAX
Tbio
Family:  TF
Novelty:  0.00799068
p_int:  0.955319245
p_ni:  0.02551803
p_wrong:  0.019162725
Data Source:  BioPlex
CHMP5
Tbio
Novelty:  0.03378716
p_int:  0.953081705
p_ni:  0.046918295
Score:  0.998
Data Source:  BioPlex,STRINGDB
SIX2
Tbio
Family:  TF
Novelty:  0.01046481
p_int:  0.910897088
p_ni:  0.089101811
p_wrong:  0.0000011
Score:  0.185
Data Source:  BioPlex,STRINGDB
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.907849711
p_ni:  0.04708827
p_wrong:  0.045062018
Data Source:  BioPlex
STAMBP
Tchem
Novelty:  0.01543821
p_int:  0.890692525
p_ni:  0.109302681
p_wrong:  0.000004794
Score:  0.839
Data Source:  BioPlex,STRINGDB
SPAST
Tbio
Novelty:  0.00303236
p_int:  0.886767684
p_ni:  0.086734805
p_wrong:  0.026497511
Score:  0.87
Data Source:  BioPlex,STRINGDB
SNAP23
Tbio
Novelty:  0.0065371
p_int:  0.864122703
p_ni:  0.135877207
p_wrong:  9e-8
Score:  0.226
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Cellular responses to external stimuli
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Autophagy
Budding and maturation of HIV virion
Cellular responses to external stimuli
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
78.7
mathematical ability
3
2
3
64
red blood cell distribution width
1
1
1
49.5
mean reticulocyte volume
1
1
1
49.5
mean platelet volume
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
78.7
mathematical ability
3
64
red blood cell distribution width
1
49.5
mean reticulocyte volume
1
49.5
mean platelet volume
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
charged multivesicular body protein 2A
VGNC:2578
456354
Macaque
charged multivesicular body protein 2A
712059
Mouse
MGI:1916203
68953
Rat
RGD:1305050
365191
Dog
charged multivesicular body protein 2A
VGNC:39222
476364
Species
Name
OMA
EggNOG
Inparanoid
Chimp
charged multivesicular body protein 2A
Macaque
charged multivesicular body protein 2A
Mouse
Rat
Dog
charged multivesicular body protein 2A
Publication Statistics
PubMed Score 612.36
PubMed score by year
PubTator Score 140.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title