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Tbio
CHML
Rab proteins geranylgeranyltransferase component A 2

Protein Summary
Description
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family. The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366553
  • ENSP00000355511
  • ENSG00000203668

Symbol
  • REP2
  • REP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.77
transcription factor perturbation
0.74
molecular function
0.73
gene perturbation
0.66
cell type or tissue
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.35   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.35   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (147)
RAB31
Tbio
Family:  Enzyme
Novelty:  0.03673084
p_int:  0.999998638
p_ni:  0.000001362
Score:  0.967
Data Source:  BioPlex,Reactome,STRINGDB
RAB9A
Tbio
Family:  Enzyme
Novelty:  0.07006531
p_int:  0.99999785
p_ni:  0.00000215
Score:  0.959
Data Source:  BioPlex,Reactome,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.999997451
p_ni:  0.000002549
Score:  0.927
Data Source:  BioPlex,STRINGDB
RAB6B
Tbio
Family:  Enzyme
Novelty:  0.0865097
p_int:  0.999996732
p_ni:  0.000003267
Score:  0.939
Data Source:  BioPlex,STRINGDB
LMO1
Tbio
Novelty:  0.01670419
p_int:  0.999992405
p_ni:  0.000007595
p_wrong:  1e-9
Data Source:  BioPlex
RAB30
Tbio
Family:  Enzyme
Novelty:  0.1262404
p_int:  0.999988783
p_ni:  0.000011203
p_wrong:  1.4e-8
Score:  0.923
Data Source:  BioPlex,STRINGDB
RASEF
Tbio
Novelty:  0.08877022
p_int:  0.999985773
p_ni:  0.000014089
p_wrong:  1.37e-7
Score:  0.352
Data Source:  BioPlex,STRINGDB
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.999980539
p_ni:  0.000019461
Score:  0.935
Data Source:  BioPlex,STRINGDB
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
p_int:  0.999968725
p_ni:  0.000031274
p_wrong:  1e-9
Score:  0.931
Data Source:  BioPlex,STRINGDB
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.999912838
p_ni:  0.00008716
p_wrong:  2e-9
Score:  0.927
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB GEFs exchange GTP for GDP on RABs
RAB geranylgeranylation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
72.1
self reported educational attainment
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
72.1
self reported educational attainment
1
62.1
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:101913
12663
Horse
CHM like, Rab escort protein 2
VGNC:16504
100054779
Cow
CHM like, Rab escort protein 2
VGNC:27298
532324
C. elegans
175311
Fruitfly
FBgn0026378
37246
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
CHM like, Rab escort protein 2
Cow
CHM like, Rab escort protein 2
C. elegans
Fruitfly
Publication Statistics
PubMed Score 174.35
PubMed score by year
PubTator Score 35.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title