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Tbio
CHL1
Neural cell adhesion molecule L1-like protein

Protein Summary
Description
Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane (By similarity). The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain canc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256509
  • ENSP00000256509
  • ENSG00000134121
  • ENST00000397491
  • ENSP00000380628

Symbol
  • CALL
  • CALL
  • L1CAM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.86
PubMedID
0.77
microRNA
0.74
disease
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1787.53   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1787.53   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
ANK1
Tbio
Novelty:  0.00225305
p_int:  0.999998813
p_ni:  0.000001187
Score:  0.942
Data Source:  BioPlex,Reactome,STRINGDB
ANK3
Tbio
Novelty:  0.00429246
p_int:  0.99999857
p_ni:  0.00000143
Score:  0.612
Data Source:  BioPlex,STRINGDB
ANK2
Tbio
Novelty:  0.00528351
p_int:  0.999971248
p_ni:  0.000028752
Score:  0.64
Data Source:  BioPlex,STRINGDB
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.934530156
p_ni:  0.065469844
Score:  0.206
Data Source:  BioPlex,STRINGDB
CNTN6
Tbio
Novelty:  0.00477805
Score:  0.947
Data Source:  Reactome,STRINGDB
NRP1
Tchem
Novelty:  0.00153628
Score:  0.931
Data Source:  Reactome,STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.925
Data Source:  Reactome,STRINGDB
ITGA1
Tbio
Novelty:  0.00545805
Score:  0.911
Data Source:  Reactome,STRINGDB
ITGA2
Tbio
Novelty:  0.0013482
Score:  0.906
Data Source:  Reactome,STRINGDB
ITGA10
Tbio
Novelty:  0.03550593
Score:  0.902
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CHL1 interactions
Reactome
Developmental Biology
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
CHL1 interactions
Developmental Biology
L1CAM interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
62.1
mathematical ability
4
4
4
60.5
risk-taking behaviour
1
2
2
47.5
self reported educational attainment
1
1
1
15.8
hair color
1
1
0
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
62.1
mathematical ability
4
60.5
risk-taking behaviour
2
47.5
self reported educational attainment
1
15.8
hair color
0
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell adhesion molecule L1 like
VGNC:7034
460126
Macaque
cell adhesion molecule L1 like
709172
Mouse
MGI:1098266
12661
Rat
Dog
cell adhesion molecule L1 like
VGNC:39219
476554
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell adhesion molecule L1 like
Macaque
cell adhesion molecule L1 like
Mouse
Rat
Dog
cell adhesion molecule L1 like
Publication Statistics
PubMed Score 1787.53
PubMed score by year
PubTator Score 93.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title