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Tbio
CHKB
Choline/ethanolamine kinase

Protein Summary
Description
Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis. Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406938
  • ENSP00000384400
  • ENSG00000100288

Symbol
  • CHETK
  • CHKL
  • CK
  • EK
  • CKB
  • EKB
  • CHKL
  • CHETK
  • CKEKB
  • MDCMC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
molecular function
0.9
histone modification site profile
0.85
cell type or tissue
0.68
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.62   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.62   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
PCYT2
Tbio
Family:  Enzyme
Novelty:  0.03267621
Score:  0.981
Data Source:  STRINGDB
PCYT1B
Tbio
Family:  Enzyme
Novelty:  0.02972878
Score:  0.972
Data Source:  STRINGDB
PCYT1A
Tchem
Family:  Enzyme
Novelty:  0.00621528
Score:  0.96
Data Source:  STRINGDB
GPCPD1
Tdark
Family:  Enzyme
Novelty:  0.03548168
Score:  0.944
Data Source:  STRINGDB
CPT1B
Tchem
Family:  Enzyme
Novelty:  0.00733077
Score:  0.922
Data Source:  STRINGDB
ETNPPL
Tbio
Family:  Enzyme
Novelty:  0.11207676
Score:  0.912
Data Source:  STRINGDB
CHKA
Tchem
Family:  Kinase
Novelty:  0.00237839
Score:  0.903
Data Source:  Reactome,STRINGDB
CHAT
Tchem
Family:  Enzyme
Novelty:  0.00033026
Score:  0.903
Data Source:  STRINGDB
ACHE
Tclin
Family:  Enzyme
Novelty:  0.00026957
Score:  0.903
Data Source:  STRINGDB
PHOSPHO1
Tchem
Family:  Enzyme
Novelty:  0.05458897
Score:  0.843
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 3 of 3
PIK3CD
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
PIK3CA
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
RAF1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
Pathways (17)
Glycerophospholipid biosynthesis (R-HSA-1483206)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PC
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PC
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
5
7
8
99
mean reticulocyte volume
1
4
4
97.6
red blood cell distribution width
4
4
4
95.6
mean corpuscular hemoglobin
3
3
3
94.6
mean corpuscular hemoglobin concentration
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
8
99
mean reticulocyte volume
4
97.6
red blood cell distribution width
4
95.6
mean corpuscular hemoglobin
3
94.6
mean corpuscular hemoglobin concentration
2
91.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
choline kinase beta
VGNC:5246
739393
Mouse
MGI:1328313
12651
Rat
RGD:61826
29367
Dog
choline kinase beta
606800
Cow
choline kinase beta
536213
Species
Name
OMA
EggNOG
Inparanoid
Chimp
choline kinase beta
Mouse
Rat
Dog
choline kinase beta
Cow
choline kinase beta
Publication Statistics
PubMed Score 111.62
PubMed score by year
PubTator Score 32.92
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title