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Tchem
CHIT1
Chitotriosidase-1

Protein Summary
Description
Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity. Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255427
  • ENSP00000255427
  • ENSG00000133063
  • ENST00000367229
  • ENSP00000356198
  • ENST00000491855
  • ENSP00000423778

Symbol
  • CHI3
  • CHIT
  • CHITD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.88
biological term
0.79
virus perturbation
0.64
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 919.29   (req: < 5)
Gene RIFs: 103   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 919.29   (req: >= 5)
Gene RIFs: 103   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (121)
ALDH3B1
Tbio
Family:  Enzyme
Novelty:  0.03330389
p_int:  0.99999994
p_ni:  6e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.998475637
p_ni:  0.0015232
p_wrong:  0.000001163
Score:  0.189
Data Source:  BioPlex,STRINGDB
RMDN1
Tdark
Novelty:  1.28615984
p_int:  0.995746321
p_ni:  0.004247665
p_wrong:  0.000006014
Score:  0.54
Data Source:  BioPlex,STRINGDB
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.977134182
p_ni:  0.022865818
Score:  0.379
Data Source:  BioPlex,STRINGDB
LYZ
Tbio
Family:  Enzyme
Novelty:  0.00151342
Score:  0.963
Data Source:  STRINGDB
HEXA
Tchem
Family:  Enzyme
Novelty:  0.01134783
Score:  0.949
Data Source:  STRINGDB
ARG1
Tchem
Family:  Enzyme
Novelty:  0.00063728
Score:  0.938
Data Source:  STRINGDB
CNN2
Tbio
Novelty:  0.02486182
Score:  0.935
Data Source:  STRINGDB
HEXB
Tchem
Family:  Enzyme
Novelty:  0.0085045
Score:  0.934
Data Source:  STRINGDB
RETN
Tbio
Novelty:  0.00062517
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Digestion of dietary carbohydrate
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Digestion of dietary carbohydrate
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
2
2
90.5
mean corpuscular volume
1
2
2
90.5
YKL40 measurement
2
2
2
90
reticulocyte measurement
2
2
2
75.1
childhood onset asthma
2
1
0
1.1
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
2
90.5
mean corpuscular volume
2
90.5
YKL40 measurement
2
90
reticulocyte measurement
2
75.1
childhood onset asthma
0
1.1
73.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chitinase 1
VGNC:5301
457641
Macaque
chitinase 1
703286
Mouse
MGI:1919134
71884
Rat
RGD:1305646
289032
Pig
chitinase 1
100512552
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chitinase 1
Macaque
chitinase 1
Mouse
Rat
Pig
chitinase 1
Publication Statistics
PubMed Score 919.29
PubMed score by year
PubTator Score 249.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title