You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
CHIC1
Cysteine-rich hydrophobic domain-containing protein 1

Protein Summary
Description
This gene encodes a cysteine-rich hydrophobic (CHIC) domain-containing protein, and is one of the few protein-coding genes found near the X-inactivation center. Studies in mouse indicate that the mouse ortholog of this gene is subject to X-inactivation in mouse. Experiments with other CHIC domain-containing family members show that the cysteine residues are palmitoylated post-translationally, resulting in membrane association. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373502
  • ENSP00000362601
  • ENSG00000204116
  • ENST00000373504
  • ENSP00000362603

Symbol
  • BRX
  • BRX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
gene perturbation
0.65
tissue
0.63
cell type or tissue
0.62
microRNA
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.37   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.37   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
KIF1BP
Tbio
Novelty:  0.03932922
p_int:  0.999283895
p_ni:  0.000716041
p_wrong:  6.5e-8
Data Source:  BioPlex
BBX
Tbio
Family:  TF
Novelty:  0.02157387
p_int:  0.997982654
p_ni:  0.002017346
Data Source:  BioPlex
ZNF92
Tbio
Family:  TF
Novelty:  0.05724663
p_int:  0.989437001
p_ni:  0.010353264
p_wrong:  0.000209735
Data Source:  BioPlex
DMWD
Tbio
Novelty:  0.04096001
p_int:  0.978583288
p_ni:  0.021416663
p_wrong:  4.9e-8
Data Source:  BioPlex
MCM9
Tbio
Family:  Enzyme
Novelty:  0.0390791
p_int:  0.934739424
p_ni:  0.061905739
p_wrong:  0.003354837
Data Source:  BioPlex
POLR3A
Tbio
Family:  Enzyme
Novelty:  0.01508849
p_int:  0.904610791
p_ni:  0.095389209
Data Source:  BioPlex
USP1
Tchem
Family:  Enzyme
Novelty:  0.0092606
p_int:  0.866057445
p_ni:  0.133942555
Data Source:  BioPlex
URI1
Tbio
Family:  Enzyme
Novelty:  0.04265162
p_int:  0.863522591
p_ni:  0.136477409
Data Source:  BioPlex
ESPL1
Tbio
Family:  Enzyme
Novelty:  0.00346666
p_int:  0.856661382
p_ni:  0.143338613
p_wrong:  4e-9
Data Source:  BioPlex
TXNDC9
Tbio
Novelty:  0.00309772
p_int:  0.856327174
p_ni:  0.143672826
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cysteine rich hydrophobic domain 1
VGNC:12250
465715
Macaque
cysteine rich hydrophobic domain 1
701720
Mouse
MGI:1344694
12212
Rat
RGD:1589722
363484
Dog
cysteine rich hydrophobic domain 1
VGNC:39215
608019
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cysteine rich hydrophobic domain 1
Macaque
cysteine rich hydrophobic domain 1
Mouse
Rat
Dog
cysteine rich hydrophobic domain 1
Publication Statistics
PubMed Score 12.37
PubMed score by year
PubTator Score 6.25
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title