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Tbio
CHI3L1
Chitinase-3-like protein 1

Protein Summary
Description
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255409
  • ENSP00000255409
  • ENSG00000133048

Symbol
  • GP39
  • ASRT7
  • GP-39
  • YK-40
  • YKL40
  • CGP-39
  • YKL-40
  • YYL-40
  • HC-gp39
  • HCGP-3P
  • hCGP-39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
gene perturbation
0.96
biological process
0.91
protein domain
0.85
PubMedID
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1082.13   (req: < 5)
Gene RIFs: 355   (req: <= 3)
Antibodies: 406   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1082.13   (req: >= 5)
Gene RIFs: 355   (req: > 3)
Antibodies: 406   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
MTRF1L
Tbio
Family:  Enzyme
Novelty:  0.08598685
p_int:  0.991706425
p_ni:  0.008293437
p_wrong:  1.38e-7
Score:  0.461
Data Source:  BioPlex,STRINGDB
CD55
Tbio
Novelty:  0.0005689
p_int:  0.985984372
p_ni:  0.014014916
p_wrong:  7.12e-7
Score:  0.455
Data Source:  BioPlex,STRINGDB
BABAM2
Tbio
Novelty:  0.00448485
p_int:  0.984076198
p_ni:  0.015917857
p_wrong:  0.000005944
Score:  0.516
Data Source:  BioPlex,STRINGDB
DDHD2
Tbio
Family:  Enzyme
Novelty:  0.04306798
p_int:  0.869952532
p_ni:  0.130047359
p_wrong:  1.1e-7
Score:  0.21
Data Source:  BioPlex,STRINGDB
CALR
Tbio
Novelty:  0.0004479
p_int:  0.784491705
p_ni:  0.215508295
Score:  0.241
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.756298879
p_ni:  0.243701121
Score:  0.167
Data Source:  BioPlex,STRINGDB
LCN2
Tbio
Family:  Enzyme
Novelty:  0.00034678
Score:  0.951
Data Source:  STRINGDB
RETN
Tbio
Novelty:  0.00062517
Score:  0.943
Data Source:  STRINGDB
HP
Tbio
Novelty:  0.00016649
Score:  0.936
Data Source:  STRINGDB
PTX3
Tbio
Novelty:  0.00153752
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (181)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
YKL40 measurement
2
2
2
90
childhood onset asthma
2
1
0
1.1
73.5
5
5
0
1
70.9
systolic blood pressure
1
1
1
42.3
blood protein measurement
1
1
1
42.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
YKL40 measurement
2
90
childhood onset asthma
0
1.1
73.5
0
1
70.9
systolic blood pressure
1
42.3
blood protein measurement
1
42.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chitinase 3 like 1
VGNC:5020
457640
Macaque
chitinase 3 like 1
703401
Mouse
MGI:1340899
12654
Rat
RGD:620874
89824
Dog
chitinase 3 like 1
VGNC:39213
490222
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chitinase 3 like 1
Macaque
chitinase 3 like 1
Mouse
Rat
Dog
chitinase 3 like 1
Publication Statistics
PubMed Score 1082.13
PubMed score by year
PubTator Score 805.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title