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Tbio
CHGA
Chromogranin-A

Protein Summary
Description
Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. The protein encoded by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216492
  • ENSP00000216492
  • ENSG00000100604
  • ENST00000613166
  • ENSP00000478198
  • ENSG00000276781

Symbol
  • CGA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
disease
0.7
biological process
0.67
biological term
0.67
PubMedID
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2885.89   (req: < 5)
Gene RIFs: 203   (req: <= 3)
Antibodies: 2646   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2885.89   (req: >= 5)
Gene RIFs: 203   (req: > 3)
Antibodies: 2646   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (180)
SAPCD2
Tbio
Novelty:  0.06798955
p_int:  0.999766392
p_ni:  0.00023359
p_wrong:  1.8e-8
Score:  0.269
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.883486649
p_ni:  0.116513301
p_wrong:  4.9e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
DENR
Tbio
Novelty:  0.00653432
p_int:  0.76724615
p_ni:  0.232733832
p_wrong:  0.000020019
Score:  0.189
Data Source:  BioPlex,STRINGDB
SCG3
Tbio
Novelty:  0.02153066
Score:  0.979
Data Source:  STRINGDB
SYP
Tbio
Novelty:  0.00021543
Score:  0.945
Data Source:  STRINGDB
CHGB
Tbio
Novelty:  0.00484507
Score:  0.943
Data Source:  STRINGDB
ENO2
Tbio
Family:  Enzyme
Novelty:  0.00016748
Score:  0.925
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.892
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.866
Data Source:  STRINGDB
SCG2
Tbio
Novelty:  0.00389492
Score:  0.86
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Antimicrobial peptides (R-HSA-6803157)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
GOC
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
54.4
body height
1
1
1
54.4
platelet count
1
1
0
3.6
44.2
platelet count
1
1
0
3.6
44.2
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
54.4
body height
1
54.4
platelet count
0
3.6
44.2
platelet count
0
3.6
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromogranin A
VGNC:13024
453120
Macaque
chromogranin A
574388
Mouse
MGI:88394
12652
Rat
RGD:2338
24258
Horse
chromogranin A
VGNC:49357
100033828
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromogranin A
Macaque
chromogranin A
Mouse
Rat
Horse
chromogranin A
Publication Statistics
PubMed Score 2885.89
PubMed score by year
PubTator Score 3416.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title