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Tbio
CHERP
Calcium homeostasis endoplasmic reticulum protein

Protein Summary
Description
Involved in calcium homeostasis, growth and proliferation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000546361
  • ENSP00000439856
  • ENSG00000085872

Symbol
  • DAN26
  • SCAF6
  • SRA1
  • DAN16
  • SCAF6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.94
histone modification site profile
0.88
virus perturbation
0.88
co-expressed gene
0.82
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.36   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.36   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (264)
RBM17
Tbio
Novelty:  0.04840999
p_int:  0.999984457
p_ni:  0.000015543
Score:  0.99
Data Source:  BioPlex,STRINGDB
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.999615757
p_ni:  0.000384243
Data Source:  BioPlex
PHF5A
Tbio
Family:  Epigenetic
Novelty:  0.02989472
p_int:  0.997223768
p_ni:  0.002776232
Score:  0.914
Data Source:  BioPlex,STRINGDB
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.993206269
p_ni:  0.006793731
Score:  0.666
Data Source:  BioPlex,STRINGDB
SFSWAP
Tdark
Novelty:  0.2236256
p_int:  0.992368193
p_ni:  0.007631807
Score:  0.739
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.991967995
p_ni:  0.008032005
Score:  0.925
Data Source:  BioPlex,STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.986381193
p_ni:  0.013618806
p_wrong:  1e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
WDFY2
Tbio
Novelty:  0.01835759
p_int:  0.979858286
p_ni:  0.020141714
Score:  0.243
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.979378277
p_ni:  0.020621723
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.978119509
p_ni:  0.021880491
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
4
4
98.9
leukocyte count
2
3
3
94.6
lymphocyte percentage of leukocytes
2
2
2
89.7
1
1
0
1.1
76.1
monocyte percentage of leukocytes
1
1
1
72.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
98.9
leukocyte count
3
94.6
lymphocyte percentage of leukocytes
2
89.7
0
1.1
76.1
monocyte percentage of leukocytes
1
72.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium homeostasis endoplasmic reticulum protein
VGNC:2577
455812
Macaque
calcium homeostasis endoplasmic reticulum protein
718689
Mouse
MGI:106417
27967
Rat
RGD:1305279
290614
Dog
calcium homeostasis endoplasmic reticulum protein
VGNC:39210
610237
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium homeostasis endoplasmic reticulum protein
Macaque
calcium homeostasis endoplasmic reticulum protein
Mouse
Rat
Dog
calcium homeostasis endoplasmic reticulum protein
Publication Statistics
PubMed Score 15.36
PubMed score by year
PubTator Score 6.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title