You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CHEK2
Serine/threonine-protein kinase Chk2

Protein Summary
Description
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphory ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328354
  • ENSP00000329178
  • ENSG00000183765
  • ENST00000348295
  • ENSP00000329012
  • ENST00000382580
  • ENSP00000372023
  • ENST00000402731
  • ENSP00000384835
  • ENST00000403642
  • ENSP00000384919
  • ENST00000404276
  • ENSP00000385747
  • ENST00000405598
  • ENSP00000386087
  • ENST00000417588
  • ENSP00000412901
  • ENST00000433728
  • ENSP00000404400
  • ENST00000448511
  • ENSP00000404567
  • ENST00000649563
  • ENSP00000496928
  • ENST00000650281
  • ENSP00000497000

Symbol
  • CDS1
  • CHK2
  • RAD53
  • CDS1
  • CHK2
  • LFS2
  • RAD53
  • hCds1
  • HuCds1
  • PP1425
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
kinase
0.99
molecular function
0.99
biological process
0.96
hub protein
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1683.44   (req: < 5)
Gene RIFs: 391   (req: <= 3)
Antibodies: 1805   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1683.44   (req: >= 5)
Gene RIFs: 391   (req: > 3)
Antibodies: 1805   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 148
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1