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Tchem
CHEK1
Serine/threonine-protein kinase Chk1

Protein Summary
Description
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CD ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428830
  • ENSP00000412504
  • ENSG00000149554
  • ENST00000438015
  • ENSP00000388648
  • ENST00000524737
  • ENSP00000432890
  • ENST00000532449
  • ENSP00000481616
  • ENST00000534070
  • ENSP00000435371
  • ENST00000544373
  • ENSP00000442317

Symbol
  • CHK1
  • CHK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
hub protein
1
biological process
0.99
drug perturbation
0.99
interacting protein
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1735.79   (req: < 5)
Gene RIFs: 355   (req: <= 3)
Antibodies: 1665   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1735.79   (req: >= 5)
Gene RIFs: 355   (req: > 3)
Antibodies: 1665   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 984
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0