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Tbio
CHDH
Choline dehydrogenase, mitochondrial

Protein Summary
Description
The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315251
  • ENSP00000319851
  • ENSG00000016391
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
kinase perturbation
0.84
histone modification site profile
0.7
cell type or tissue
0.66
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.38   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.38   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.999922883
p_ni:  0.000061236
p_wrong:  0.000015881
Data Source:  BioPlex
TRMT1
Tbio
Family:  Enzyme
Novelty:  0.01795504
p_int:  0.999553207
p_ni:  0.0004081
p_wrong:  0.000038692
Score:  0.561
Data Source:  BioPlex,STRINGDB
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.999391426
p_ni:  0.000555463
p_wrong:  0.00005311
Score:  0.229
Data Source:  BioPlex,STRINGDB
TMEM70
Tbio
Novelty:  0.03111438
p_int:  0.999150962
p_ni:  0.000821339
p_wrong:  0.000027698
Score:  0.189
Data Source:  BioPlex,STRINGDB
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.998422725
p_ni:  0.00001134
p_wrong:  0.001565935
Score:  0.175
Data Source:  BioPlex,STRINGDB
ALDH7A1
Tbio
Family:  Enzyme
Novelty:  0.00069494
Score:  0.974
Data Source:  STRINGDB
PEMT
Tbio
Family:  Enzyme
Novelty:  0.00786252
Score:  0.942
Data Source:  STRINGDB
PISD
Tbio
Family:  Enzyme
Novelty:  0.00966227
Score:  0.919
Data Source:  STRINGDB
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
Score:  0.85
Data Source:  STRINGDB
CEPT1
Tchem
Family:  Enzyme
Novelty:  0.01816476
Score:  0.839
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Choline catabolism (R-HSA-6798163)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Choline catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Choline catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
2
2
2
81
body mass index
4
2
4
72.8
testosterone measurement
2
2
2
72.4
interleukin 17 receptor B measurement
1
1
1
70.2
refractive error measurement
2
2
1
6.5
58.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
2
81
body mass index
4
72.8
testosterone measurement
2
72.4
interleukin 17 receptor B measurement
1
70.2
refractive error measurement
1
6.5
58.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
choline dehydrogenase
VGNC:1775
460450
Macaque
choline dehydrogenase
693805
Mouse
MGI:1860776
218865
Rat
RGD:735166
290551
Dog
choline dehydrogenase
VGNC:39208
484723
Species
Name
OMA
EggNOG
Inparanoid
Chimp
choline dehydrogenase
Macaque
choline dehydrogenase
Mouse
Rat
Dog
choline dehydrogenase
Publication Statistics
PubMed Score 44.38
PubMed score by year
PubTator Score 219.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title