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Tbio
CHD8
Chromodomain-helicase-DNA-binding protein 8

Protein Summary
Description
DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399982
  • ENSP00000382863
  • ENSG00000100888
  • ENST00000430710
  • ENSP00000406288
  • ENST00000557364
  • ENSP00000451601
  • ENST00000643469
  • ENSP00000495070
  • ENST00000645929
  • ENSP00000494402
  • ENST00000646647
  • ENSP00000495240

Symbol
  • HELSNF1
  • KIAA1564
  • AUTS18
  • HELSNF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.97
disease perturbation
0.96
interacting protein
0.91
biological process
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.39   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.39   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0