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Tbio
CHD5
Chromodomain-helicase-DNA-binding protein 5

Protein Summary
Description
Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of fun ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262450
  • ENSP00000262450
  • ENSG00000116254

Symbol
  • KIAA0444
  • CHD-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
biological process
0.81
cellular component
0.66
protein complex
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.28   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.28   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
p_int:  0.999999975
p_ni:  2.5e-8
Score:  0.17
Data Source:  BioPlex,STRINGDB
GATAD2A
Tbio
Novelty:  0.05599551
p_int:  0.999999969
p_ni:  3.1e-8
Score:  0.969
Data Source:  BioPlex,STRINGDB
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.999999961
p_ni:  3.9e-8
Score:  0.867
Data Source:  BioPlex,STRINGDB
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.999999932
p_ni:  6.8e-8
Score:  0.841
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999917
p_ni:  8.3e-8
Score:  0.947
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999999172
p_ni:  8.28e-7
Score:  0.973
Data Source:  BioPlex,STRINGDB
HDAC2
Tclin
Family:  Epigenetic
Novelty:  0.0011024
Score:  0.975
Data Source:  STRINGDB
MTA1
Tbio
Family:  TF
Novelty:  0.00464618
Score:  0.972
Data Source:  STRINGDB
MTA2
Tbio
Family:  TF
Novelty:  0.01525806
Score:  0.969
Data Source:  STRINGDB
MTA3
Tbio
Family:  TF
Novelty:  0.02667635
Score:  0.878
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
6
4
3
1.7
92.5
TPE interval measurement
1
1
3
78.5
electrocardiography
1
1
46
78.1
T wave morphology measurement
2
1
2
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
3
1.7
92.5
TPE interval measurement
3
78.5
electrocardiography
46
78.1
T wave morphology measurement
2
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3036258
269610
Rat
RGD:1582725
691589
Dog
chromodomain helicase DNA binding protein 5
VGNC:39203
489627
Horse
chromodomain helicase DNA binding protein 5
VGNC:16487
100059711
Opossum
chromodomain helicase DNA binding protein 5 [Source:HGNC Symbol;Acc:HGNC:16816]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
chromodomain helicase DNA binding protein 5
Horse
chromodomain helicase DNA binding protein 5
Opossum
chromodomain helicase DNA binding protein 5 [Source:HGNC Symbol;Acc:HGNC:16816]
Publication Statistics
PubMed Score 18.28
PubMed score by year
PubTator Score 50.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title