CHCHD10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial
Protein Summary
May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure. This gene encodes a mitochondrial protein that is enriched at cristae junctions in the intermembrane space. It may play a role in cristae morphology maintenance or oxidative phosphorylation. Mutations in this gene cause frontotemporal dementia and/or amyotrophic lateral sclerosis-2. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 7 and 19. [provided by RefSeq, Aug 2014]
- ENST00000484558
- ENSP00000418428
- ENSG00000250479
- ENST00000629095
- ENSP00000487006
- ENSG00000273607
- C22orf16
- IMMD
- SMAJ
- MIX17A
- FTDALS2
- N27C7-4
- C22orf16
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
small molecule perturbation | 0.98 | ||
cell type or tissue | 0.74 | ||
biological process | 0.7 | ||
transcription factor binding site profile | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 106.35 (req: < 5)
Gene RIFs: 43 (req: <= 3)
Antibodies: 73 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 106.35 (req: >= 5)
Gene RIFs: 43 (req: > 3)
Antibodies: 73 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0