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Tbio
CHAMP1
Chromosome alignment-maintaining phosphoprotein 1

Protein Summary
Description
Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore. This gene encodes a zinc finger protein that functions as a regulator of chromosome segregation in mitosis. The encoded protein is required for correct alignment of chromosomes on the metaphase plate, and plays a role in maintaining the attachment of sister kinetochores to microtubules from opposite spindle poles. Mutations in this gene are associated with an autosomal dominant form of intellectual disability. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361283
  • ENSP00000354730
  • ENSG00000198824
  • ENST00000643483
  • ENSP00000496699

Symbol
  • C13orf8
  • CAMP
  • CHAMP
  • KIAA1802
  • ZNF828
  • CAMP
  • CHAMP
  • MRD40
  • ZNF828
  • C13orf8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.96
histone modification site profile
0.85
drug perturbation
0.71
tissue
0.67
microRNA
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.58   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.58   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
ZNF428
Tdark
Novelty:  3.23887218
p_int:  0.999999941
p_ni:  1.9e-8
p_wrong:  4e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.999994975
p_ni:  0.000005025
Data Source:  BioPlex
TMEM171
Tdark
Novelty:  2.00247773
p_int:  0.999987565
p_ni:  0.000012435
Score:  0.158
Data Source:  BioPlex,STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
p_int:  0.99997882
p_ni:  0.000021171
p_wrong:  9e-9
Data Source:  BioPlex
PHF19
Tbio
Family:  Epigenetic
Novelty:  0.02289037
p_int:  0.999561017
p_ni:  0.000438381
p_wrong:  6.02e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
DEF6
Tbio
Novelty:  0.0378487
p_int:  0.994223099
p_ni:  0.005668389
p_wrong:  0.000108512
Score:  0.213
Data Source:  BioPlex,STRINGDB
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.897685608
p_ni:  0.013686809
p_wrong:  0.088627583
Data Source:  BioPlex
RAD50
Tbio
Novelty:  0.02161298
Score:  0.976
Data Source:  STRINGDB
POGZ
Tbio
Novelty:  0.03603188
Score:  0.857
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
82
BMI-adjusted hip circumference
1
2
2
45.6
1
1
0
1.4
14.2
body height
1
1
1
12.2
monocyte percentage of leukocytes
1
1
1
9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
82
BMI-adjusted hip circumference
2
45.6
0
1.4
14.2
body height
1
12.2
monocyte percentage of leukocytes
1
9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
chromosome alignment maintaining phosphoprotein 1
699474
Mouse
MGI:1196398
101994
Rat
RGD:1311283
306647
Dog
chromosome alignment maintaining phosphoprotein 1
VGNC:39191
100688496
Horse
chromosome alignment maintaining phosphoprotein 1
VGNC:16477
100069305
Species
Name
OMA
EggNOG
Inparanoid
Macaque
chromosome alignment maintaining phosphoprotein 1
Mouse
Rat
Dog
chromosome alignment maintaining phosphoprotein 1
Horse
chromosome alignment maintaining phosphoprotein 1
Publication Statistics
PubMed Score 14.58
PubMed score by year
PubTator Score 47.27
PubTator score by year
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Related Publications
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PMID
Year
Title