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Tbio
CHAF1B
Chromatin assembly factor 1 subunit B

Protein Summary
Description
Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314103
  • ENSP00000315700
  • ENSG00000159259

Symbol
  • CAF1A
  • CAF1P60
  • MPHOSPH7
  • MPP7
  • CAF1
  • MPP7
  • CAF-1
  • CAF1A
  • CAF1P60
  • CAF-IP60
  • MPHOSPH7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor perturbation
0.84
histone modification site profile
0.83
tissue sample
0.77
interacting protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.87   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 273   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.87   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (161)
HIST1H3A
Tbio
Novelty:  0.00991842
p_int:  0.995274229
p_ni:  0.004725771
Score:  0.546
Data Source:  BioPlex,STRINGDB
ASF1B
Tbio
Novelty:  0.05716701
p_int:  0.982264418
p_ni:  0.017735582
Score:  0.991
Data Source:  BioPlex,STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.932365947
p_ni:  0.067634053
Score:  0.521
Data Source:  BioPlex,STRINGDB
RAB33B
Tbio
Family:  Enzyme
Novelty:  0.06381712
p_int:  0.927194294
p_ni:  0.072805706
Data Source:  BioPlex
INSL3
Tbio
Novelty:  0.00374656
p_int:  0.901943541
p_ni:  0.098056459
Score:  0.513
Data Source:  BioPlex,STRINGDB
CEP72
Tbio
Novelty:  0.06830459
p_int:  0.803850378
p_ni:  0.196149622
Score:  0.262
Data Source:  BioPlex,STRINGDB
CHAF1A
Tbio
Novelty:  0.02129179
Score:  0.997
Data Source:  STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.988
Data Source:  STRINGDB
ASF1A
Tchem
Novelty:  0.02544466
Score:  0.973
Data Source:  STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.2
89.2
hematocrit
4
1
4
84.9
hemoglobin measurement
3
1
3
84
red blood cell density measurement
1
1
1
82
urate measurement
1
1
1
76.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
89.2
hematocrit
4
84.9
hemoglobin measurement
3
84
red blood cell density measurement
1
82
urate measurement
1
76.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromatin assembly factor 1 subunit B
VGNC:3737
470084
Macaque
chromatin assembly factor 1 subunit B
695206
Mouse
MGI:1314881
110749
Rat
RGD:1307634
288242
Dog
chromatin assembly factor 1 subunit B
VGNC:39190
487750
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromatin assembly factor 1 subunit B
Macaque
chromatin assembly factor 1 subunit B
Mouse
Rat
Dog
chromatin assembly factor 1 subunit B
Publication Statistics
PubMed Score 20.87
PubMed score by year
PubTator Score 14.39
PubTator score by year
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Related Publications
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PMID
Year
Title