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Tbio
CHAF1A
Chromatin assembly factor 1 subunit A

Protein Summary
Description
Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301280
  • ENSP00000301280
  • ENSG00000167670

Symbol
  • CAF
  • CAF1P150
  • CAF1
  • P150
  • CAF-1
  • CAF1B
  • CAF1P150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
hub protein
0.85
transcription factor binding site profile
0.85
interacting protein
0.66
transcription factor
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.57   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.57   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (202)
HIST1H3A
Tbio
Novelty:  0.00991842
p_int:  0.999999405
p_ni:  5.95e-7
Score:  0.458
Data Source:  BioPlex,STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.999998637
p_ni:  0.000001363
Score:  0.458
Data Source:  BioPlex,STRINGDB
ASF1B
Tbio
Novelty:  0.05716701
p_int:  0.999843515
p_ni:  0.000156482
p_wrong:  3e-9
Score:  0.955
Data Source:  BioPlex,STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.998316985
p_ni:  0.001683015
Data Source:  BioPlex
CHAF1B
Tbio
Novelty:  0.05899435
Score:  0.997
Data Source:  STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.971
Data Source:  STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
Score:  0.939
Data Source:  STRINGDB
BAZ1B
Tbio
Family:  Epigenetic
Novelty:  0.02374034
Score:  0.936
Data Source:  STRINGDB
SMARCD1
Tbio
Novelty:  0.03176642
Score:  0.933
Data Source:  STRINGDB
ACTL6A
Tbio
Novelty:  0.01892162
Score:  0.929
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
3
3
97.8
red blood cell distribution width
4
3
5
96.6
hemoglobin measurement
3
3
4
95.9
mean reticulocyte volume
1
2
2
95.1
mean corpuscular hemoglobin concentration
3
1
3
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
97.8
red blood cell distribution width
5
96.6
hemoglobin measurement
4
95.9
mean reticulocyte volume
2
95.1
mean corpuscular hemoglobin concentration
3
88.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chromatin assembly factor 1 subunit A
VGNC:6617
455603
Macaque
chromatin assembly factor 1 subunit A
721861
Mouse
MGI:1351331
27221
Rat
RGD:1590865
363333
Dog
chromatin assembly factor 1 subunit A
VGNC:39189
485038
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chromatin assembly factor 1 subunit A
Macaque
chromatin assembly factor 1 subunit A
Mouse
Rat
Dog
chromatin assembly factor 1 subunit A
Publication Statistics
PubMed Score 54.57
PubMed score by year
PubTator Score 306.86
PubTator score by year
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Related Publications
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PMID
Year
Title