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Tbio
CHAC2
Glutathione-specific gamma-glutamylcyclotransferase 2

Protein Summary
Description
Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295304
  • ENSP00000295304
  • ENSG00000143942

Symbol
  • GCG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
cell type or tissue
0.56
transcription factor binding site profile
0.55
tissue sample
0.54
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.47   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.47   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
HAPLN3
Tbio
Novelty:  0.19545048
p_int:  0.999980243
p_ni:  0.00001975
p_wrong:  7e-9
Score:  0.297
Data Source:  BioPlex,STRINGDB
SCAF1
Tbio
Novelty:  0.08705338
p_int:  0.999848643
p_ni:  0.000151356
Data Source:  BioPlex
STMN3
Tbio
Novelty:  0.05061958
p_int:  0.993353535
p_ni:  0.006646465
Data Source:  BioPlex
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.986005579
p_ni:  0.000123387
p_wrong:  0.013871034
Score:  0.188
Data Source:  BioPlex,STRINGDB
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.966097092
p_ni:  0.033902908
Score:  0.268
Data Source:  BioPlex,STRINGDB
BTN3A1
Tchem
Novelty:  0.02572232
p_int:  0.864778648
p_ni:  0.12944055
p_wrong:  0.005780802
Data Source:  BioPlex
TOM1
Tbio
Novelty:  0.00725956
p_int:  0.860178272
p_ni:  0.139821082
p_wrong:  6.46e-7
Data Source:  BioPlex
ZNF577
Tdark
Family:  TF
Novelty:  0.29636548
p_int:  0.854627241
p_ni:  0.145368448
p_wrong:  0.000004312
Data Source:  BioPlex
CARM1
Tchem
Family:  Epigenetic
Novelty:  0.00623937
p_int:  0.829398975
p_ni:  0.170601025
Data Source:  BioPlex
SP5
Tdark
Family:  TF
Novelty:  0.16814294
Score:  0.757
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Glutathione synthesis and recycling
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Glutathione synthesis and recycling
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
83.2
reticulocyte measurement
2
2
2
79.8
hemoglobin measurement
2
2
2
79.2
hematocrit
2
1
2
71.6
lymphocyte count
2
2
2
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
83.2
reticulocyte measurement
2
79.8
hemoglobin measurement
2
79.2
hematocrit
2
71.6
lymphocyte count
2
70.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ChaC cation transport regulator homolog 2
VGNC:10296
459228
Macaque
ChaC cation transport regulator homolog 2
100427277
Mouse
MGI:1915294
68044
Rat
RGD:1309120
360994
Dog
ChaC cation transport regulator homolog 2
VGNC:39186
612017
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ChaC cation transport regulator homolog 2
Macaque
ChaC cation transport regulator homolog 2
Mouse
Rat
Dog
ChaC cation transport regulator homolog 2
Publication Statistics
PubMed Score 8.47
PubMed score by year
PubTator Score 1.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title