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Tbio
CH25H
Cholesterol 25-hydroxylase

Protein Summary
Description
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a sma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371852
  • ENSP00000360918
  • ENSG00000138135

Symbol
  • C25H
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.89
histone modification site profile
0.82
PubMedID
0.69
tissue sample
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.34   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.34   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
CYP7B1
Tbio
Family:  Enzyme
Novelty:  0.01164653
Score:  0.988
Data Source:  STRINGDB
CYP46A1
Tchem
Family:  Enzyme
Novelty:  0.01549935
Score:  0.971
Data Source:  STRINGDB
CYP7A1
Tchem
Family:  Enzyme
Novelty:  0.00148194
Score:  0.966
Data Source:  STRINGDB
CYP27A1
Tchem
Family:  Enzyme
Novelty:  0.00071796
Score:  0.958
Data Source:  STRINGDB
DHCR7
Tchem
Family:  Enzyme
Novelty:  0.00358937
Score:  0.906
Data Source:  STRINGDB
LIPA
Tchem
Family:  Enzyme
Novelty:  0.00164907
Score:  0.887
Data Source:  STRINGDB
DHCR24
Tchem
Family:  Enzyme
Novelty:  0.00480473
Score:  0.877
Data Source:  STRINGDB
SOAT1
Tchem
Family:  Enzyme
Novelty:  0.00530755
Score:  0.874
Data Source:  STRINGDB
SQLE
Tchem
Family:  Enzyme
Novelty:  0.0059338
Score:  0.85
Data Source:  STRINGDB
SOAT2
Tchem
Family:  Enzyme
Novelty:  0.01860981
Score:  0.823
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (56)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Synthesis of bile acids and bile salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Synthesis of bile acids and bile salts
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
3
4
1.1
98
C-reactive protein measurement
6
4
6
97.5
5
4
2
1.1
96.1
neutrophil count
4
3
4
82.3
blood protein measurement
3
3
3
70
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
98
C-reactive protein measurement
6
97.5
2
1.1
96.1
neutrophil count
4
82.3
blood protein measurement
3
70
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholesterol 25-hydroxylase
VGNC:7224
450584
Mouse
MGI:1333869
12642
Rat
RGD:1310575
309527
Dog
cholesterol 25-hydroxylase
VGNC:52926
100856263
Horse
cholesterol 25-hydroxylase
VGNC:16472
100062138
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholesterol 25-hydroxylase
Mouse
Rat
Dog
cholesterol 25-hydroxylase
Horse
cholesterol 25-hydroxylase
Publication Statistics
PubMed Score 91.34
PubMed score by year
PubTator Score 33.69
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title