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Tbio
CGNL1
Cingulin-like protein 1

Protein Summary
Description
May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281282
  • ENSP00000281282
  • ENSG00000128849

Symbol
  • JACOP
  • KIAA1749
  • JACOP
  • PCING
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.71
histone modification site profile
0.69
cell type or tissue
0.64
microRNA
0.64
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.74   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.74   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
TRAF7
Tbio
Family:  Enzyme
Novelty:  0.02437761
p_int:  0.966424264
p_ni:  0.033574079
p_wrong:  0.000001657
Score:  0.181
Data Source:  BioPlex,STRINGDB
NDE1
Tbio
Novelty:  0.00567438
p_int:  0.946457582
p_ni:  0.053542418
Score:  0.187
Data Source:  BioPlex,STRINGDB
HMMR
Tchem
Novelty:  0.0039196
p_int:  0.849276342
p_ni:  0.150634045
p_wrong:  0.000089613
Score:  0.19
Data Source:  BioPlex,STRINGDB
GRIPAP1
Tbio
Novelty:  0.09814766
p_int:  0.803705456
p_ni:  0.196294543
p_wrong:  1e-9
Score:  0.332
Data Source:  BioPlex,STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
Score:  0.901
Data Source:  STRINGDB
TMOD2
Tbio
Novelty:  0.10324176
Score:  0.746
Data Source:  STRINGDB
CYP19A1
Tclin
Family:  Enzyme
Novelty:  0.0003187
Score:  0.711
Data Source:  STRINGDB
PLEKHA7
Tbio
Novelty:  0.05239328
Score:  0.694
Data Source:  STRINGDB
CLDN12
Tbio
Novelty:  0.04404633
Score:  0.67
Data Source:  STRINGDB
EEA1
Tbio
Novelty:  0.00242832
Score:  0.63
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
3
3
5.5
72.8
hematocrit
2
2
2
60.8
red blood cell density measurement
1
1
1
46.5
hemoglobin measurement
1
1
1
45.2
creatinine measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
5.5
72.8
hematocrit
2
60.8
red blood cell density measurement
1
46.5
hemoglobin measurement
1
45.2
creatinine measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cingulin like 1
VGNC:11841
453467
Macaque
cingulin-like protein 1
699876
Mouse
MGI:1915428
68178
Rat
RGD:1304623
315795
Dog
cingulin like 1
VGNC:39184
487574
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cingulin like 1
Macaque
cingulin-like protein 1
Mouse
Rat
Dog
cingulin like 1
Publication Statistics
PubMed Score 20.74
PubMed score by year
PubTator Score 5.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title