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Tbio
CGGBP1
CGG triplet repeat-binding protein 1

Protein Summary
Description
Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter. This gene encodes a CGG repeat-binding protein that primarily localizes to the nucleus. CGG trinucleotide repeats are implicated in many disorders as they often act as transcription- and translation-regulatory elements, can produce hairpin structures which cause DNA replication errors, and form regions prone to chromosomal breakage. CGG repeats are also targets for CpG methylation. In addition to its ability to bind CGG repeats and regulate transcription, this gene is believed to play a role in DNA damage repair and telomere protection. In vitro studies indicate this protein does not bind to methylated CpG sequences. [provided by RefSeq, Jul 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309534
  • ENSP00000381428
  • ENSG00000163320
  • ENST00000398392
  • ENSP00000381429
  • ENST00000462901
  • ENSP00000418769
  • ENST00000482016
  • ENSP00000420374

Symbol
  • CGGBP
  • CGGBP
  • p20-CGGBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.91
histone modification site profile
0.82
transcription factor binding site profile
0.8
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.45   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.45   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
SPIN2B
Tchem
Novelty:  0.23202718
p_int:  0.999999954
p_ni:  4.6e-8
Score:  0.795
Data Source:  BioPlex,STRINGDB
SPIN1
Tchem
Novelty:  0.00889909
p_int:  0.999999582
p_ni:  4.18e-7
Score:  0.825
Data Source:  BioPlex,STRINGDB
MRM1
Tbio
Family:  Enzyme
Novelty:  0.08762499
p_int:  0.999864444
p_ni:  0.000131028
p_wrong:  0.000004528
Score:  0.157
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.981203957
p_ni:  0.018695654
p_wrong:  0.000100389
Data Source:  BioPlex
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.928824188
p_ni:  0.071170965
p_wrong:  0.000004847
Data Source:  BioPlex
RNF111
Tbio
Family:  Enzyme
Novelty:  0.03059486
p_int:  0.904999131
p_ni:  0.094994785
p_wrong:  0.000006084
Score:  0.218
Data Source:  BioPlex,STRINGDB
MEMO1
Tbio
Novelty:  0.0506558
p_int:  0.872145225
p_ni:  0.127854775
Data Source:  BioPlex
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
p_int:  0.854601056
p_ni:  0.000234339
p_wrong:  0.145164605
Data Source:  BioPlex
KLHL8
Tdark
Novelty:  0.4838314
p_int:  0.847804443
p_ni:  0.149945809
p_wrong:  0.002249748
Data Source:  BioPlex
DDB1
Tbio
Novelty:  0.00345896
Score:  0.869
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
3
3
84.6
mean corpuscular hemoglobin concentration
1
1
1
67.5
1
1
1
66.8
substance abuse
1
1
1
66.8
antisocial behaviour measurement
1
1
1
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
84.6
mean corpuscular hemoglobin concentration
1
67.5
1
66.8
substance abuse
1
66.8
antisocial behaviour measurement
1
66.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2146370
106143
Rat
RGD:1308129
288353
Dog
CGG triplet repeat binding protein 1
VGNC:39182
478375
Horse
CGG triplet repeat binding protein 1
VGNC:16469
100054431
Cow
CGG triplet repeat binding protein 1
613824
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
CGG triplet repeat binding protein 1
Horse
CGG triplet repeat binding protein 1
Cow
CGG triplet repeat binding protein 1
Publication Statistics
PubMed Score 15.45
PubMed score by year
PubTator Score 9.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title