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Tchem
CGAS
Cyclic GMP-AMP synthase

Protein Summary
Description
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP (PubMed:23258413, PubMed:23707061, PubMed:23722159, PubMed:24077100, PubMed:25131990). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-1, by dete ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370315
  • ENSP00000359339
  • ENSG00000164430
  • ENST00000370318
  • ENSP00000359342

Symbol
  • C6orf150
  • MB21D1
  • MB21D1
  • h-cGAS
  • C6orf150
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 591.76   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 591.76   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (2)
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (61)
BX-795
Rendered image for BX-795
alpha-mangostin
Rendered image for alpha-mangostin
CHEMBL4448176
Rendered image for CHEMBL4448176
CHEMBL4096573
Rendered image for CHEMBL4096573
CHEMBL4483323
Rendered image for CHEMBL4483323
CHEMBL4474744
Rendered image for CHEMBL4474744
CHEMBL4553894
Rendered image for CHEMBL4553894
CHEMBL4573520
Rendered image for CHEMBL4573520
CHEMBL4528559
Rendered image for CHEMBL4528559
Protein-Protein Interactions (102)
ZNF593
Tbio
Novelty:  0.45276787
p_int:  0.774754208
p_ni:  0.225244676
p_wrong:  0.000001116
Score:  0.359
Data Source:  BioPlex,STRINGDB
TMEM173
Tchem
Novelty:  0.0070581
Score:  0.973
Data Source:  STRINGDB
IFI16
Tbio
Novelty:  0.00739446
Score:  0.89
Data Source:  STRINGDB
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
Score:  0.802
Data Source:  STRINGDB
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
Score:  0.789
Data Source:  STRINGDB
IFNB1
Tbio
Novelty:  0.00011797
Score:  0.776
Data Source:  STRINGDB
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.765
Data Source:  STRINGDB
RNF185
Tbio
Family:  Enzyme
Novelty:  0.23911257
Score:  0.762
Data Source:  STRINGDB
AIM2
Tbio
Novelty:  0.00360474
Score:  0.743
Data Source:  STRINGDB
DDX41
Tbio
Family:  Enzyme
Novelty:  0.01658581
Score:  0.717
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (31)
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)

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1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Immune System
Reactome
Innate Immune System
Reactome
STING mediated induction of host immune responses
Name
Explore in Pharos
Explore in Source
Cytosolic sensors of pathogen-associated DNA
Immune System
Innate Immune System
STING mediated induction of host immune responses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclic GMP-AMP synthase
VGNC:7205
462822
Macaque
cyclic GMP-AMP synthase
717665
Mouse
MGI:2442261
214763
Rat
RGD:1586939
682147
Dog
cyclic GMP-AMP synthase
VGNC:43047
611033
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclic GMP-AMP synthase
Macaque
cyclic GMP-AMP synthase
Mouse
Rat
Dog
cyclic GMP-AMP synthase
Publication Statistics
PubMed Score 591.76
PubMed score by year
PubTator Score 94.18
PubTator score by year
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Related Publications
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PMID
Year
Title