Protein Summary
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP (PubMed:23258413, PubMed:23707061, PubMed:23722159, PubMed:24077100, PubMed:25131990). Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p] (PubMed:28363908, PubMed:28214358). Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production (PubMed:28363908, PubMed:28314590). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses, such as HIV-1, by dete ...more
- ENST00000370315
- ENSP00000359339
- ENSG00000164430
- ENST00000370318
- ENSP00000359342
- C6orf150
- MB21D1
- MB21D1
- h-cGAS
- C6orf150
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 591.76 (req: < 5)
Gene RIFs: 64 (req: <= 3)
Antibodies: 189 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 591.76 (req: >= 5)
Gene RIFs: 64 (req: > 3)
Antibodies: 189 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 61
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (2)
Approved Drugs (0)
Active Ligands (61)
Protein-Protein Interactions (102)
ZNF593
Novelty: 0.45276787
p_int: 0.774754208
p_ni: 0.225244676
p_wrong: 0.000001116
Score: 0.359
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (31)
Reactome (4)
KEGG (4)
WikiPathways (23)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytosolic sensors of pathogen-associated DNA | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | STING mediated induction of host immune responses | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytosolic sensors of pathogen-associated DNA | ||||
Immune System | ||||
Innate Immune System | ||||
STING mediated induction of host immune responses | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (7)
Components (1)
Processes (11)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cyclic GMP-AMP synthase | VGNC:7205 | 462822 | |||||
Macaque | cyclic GMP-AMP synthase | 717665 | ||||||
Mouse | MGI:2442261 | 214763 | ||||||
Rat | RGD:1586939 | 682147 | ||||||
Dog | cyclic GMP-AMP synthase | VGNC:43047 | 611033 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cyclic GMP-AMP synthase | |||||
Macaque | cyclic GMP-AMP synthase | |||||
Mouse | ||||||
Rat | ||||||
Dog | cyclic GMP-AMP synthase | |||||
Publication Statistics
PubMed Score 591.76
PubMed score by year
PubTator Score 94.18
PubTator score by year
Related Publications
Text Mined References (77)
GeneRif Annotations (64)
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