You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CFTR
Cystic fibrosis transmembrane conductance regulator

Protein Summary
Description
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000003084
  • ENSP00000003084
  • ENSG00000001626
  • ENST00000649781
  • ENSP00000497203

Symbol
  • ABCC7
  • CF
  • MRP7
  • ABC35
  • ABCC7
  • CFTR/MRP
  • TNR-CFTR
  • dJ760C5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
molecular function
1
kinase perturbation
0.95
biological process
0.94
hub protein
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2570.52   (req: < 5)
Gene RIFs: 1206   (req: <= 3)
Antibodies: 999   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2570.52   (req: >= 5)
Gene RIFs: 1206   (req: > 3)
Antibodies: 999   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 454
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7