Protein Summary
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]
- ENST00000247153
- ENSP00000247153
- ENSG00000126759
- ENST00000396992
- ENSP00000380189
- PFC
- BFD
- PFC
- PFD
- PROPERDIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.65 | ||
tissue sample | 0.61 | ||
transcription factor perturbation | 0.61 | ||
PubMedID | 0.58 | ||
cell line | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1604.17 (req: < 5)
Gene RIFs: 30 (req: <= 3)
Antibodies: 486 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1604.17 (req: >= 5)
Gene RIFs: 30 (req: > 3)
Antibodies: 486 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (216)
B3GLCT
Family: Enzyme
Novelty: 0.02398944
p_int: 0.999997212
p_ni: 0.000002788
Score: 0.959
Data Source: BioPlex,STRINGDB
DPY19L3
Family: Enzyme
Novelty: 0.35244121
p_int: 0.999954063
p_ni: 0.000045924
p_wrong: 1.4e-8
Score: 0.332
Data Source: BioPlex,STRINGDB
CRTAC1
Novelty: 0.09442374
p_int: 0.99979194
p_ni: 0.00020805
p_wrong: 9e-9
Score: 0.201
Data Source: BioPlex,STRINGDB
CRBN
Novelty: 0.00385433
p_int: 0.941797161
p_ni: 0.009356731
p_wrong: 0.048846108
Score: 0.19
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (14)
Reactome (11)
KEGG (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective B3GALTL causes Peters-plus syndrome (PpS) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (1)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:97545 | 18636 | ||||||
Rat | RGD:1594557 | 299314 | ||||||
Dog | complement factor properdin | VGNC:39179 | 491859 | |||||
Horse | complement factor properdin | VGNC:16467 | 100051317 | |||||
Cow | complement factor properdin | VGNC:27256 | 539605 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | complement factor properdin | |||||
Horse | complement factor properdin | |||||
Cow | complement factor properdin | |||||
Publication Statistics
PubMed Score 1604.17
PubMed score by year
PubTator Score 486.44
PubTator score by year
Related Publications
Text Mined References (61)
GeneRif Annotations (30)
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