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Tbio
CFP
Properdin

Protein Summary
Description
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247153
  • ENSP00000247153
  • ENSG00000126759
  • ENST00000396992
  • ENSP00000380189

Symbol
  • PFC
  • BFD
  • PFC
  • PFD
  • PROPERDIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.65
tissue sample
0.61
transcription factor perturbation
0.61
PubMedID
0.58
cell line
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1604.17   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 486   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1604.17   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 486   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (216)
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
p_int:  0.999997212
p_ni:  0.000002788
Score:  0.959
Data Source:  BioPlex,STRINGDB
DPY19L3
Tbio
Family:  Enzyme
Novelty:  0.35244121
p_int:  0.999954063
p_ni:  0.000045924
p_wrong:  1.4e-8
Score:  0.332
Data Source:  BioPlex,STRINGDB
CRTAC1
Tbio
Novelty:  0.09442374
p_int:  0.99979194
p_ni:  0.00020805
p_wrong:  9e-9
Score:  0.201
Data Source:  BioPlex,STRINGDB
CRBN
Tclin
Novelty:  0.00385433
p_int:  0.941797161
p_ni:  0.009356731
p_wrong:  0.048846108
Score:  0.19
Data Source:  BioPlex,STRINGDB
C7
Tbio
Novelty:  0.01540501
Score:  0.962
Data Source:  STRINGDB
PTX3
Tbio
Novelty:  0.00153752
Score:  0.949
Data Source:  STRINGDB
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
Score:  0.944
Data Source:  STRINGDB
C5
Tclin
Novelty:  0.00225386
Score:  0.942
Data Source:  Reactome,STRINGDB
ADAMTSL1
Tbio
Novelty:  0.08853044
Score:  0.941
Data Source:  STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.935
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

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Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
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IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:97545
18636
Rat
RGD:1594557
299314
Dog
complement factor properdin
VGNC:39179
491859
Horse
complement factor properdin
VGNC:16467
100051317
Cow
complement factor properdin
VGNC:27256
539605
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
complement factor properdin
Horse
complement factor properdin
Cow
complement factor properdin
Publication Statistics
PubMed Score 1604.17
PubMed score by year
PubTator Score 486.44
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title