You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CFH
Complement factor H

Protein Summary
Description
Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway. This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367429
  • ENSP00000356399
  • ENSG00000000971

Symbol
  • HF
  • HF1
  • HF2
  • FH
  • HF
  • HF1
  • HF2
  • HUS
  • FHL1
  • AHUS1
  • AMBP1
  • ARMD4
  • ARMS1
  • CFHL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
co-expressed gene
0.99
gene perturbation
0.96
disease
0.89
phenotype
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1979.64   (req: < 5)
Gene RIFs: 595   (req: <= 3)
Antibodies: 855   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1979.64   (req: >= 5)
Gene RIFs: 595   (req: > 3)
Antibodies: 855   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
CFHR3
Tbio
Novelty:  0.01779009
p_int:  0.99551977
p_ni:  4.07e-7
p_wrong:  0.004479823
Score:  0.966
Data Source:  BioPlex,STRINGDB
KLHL18
Tdark
Novelty:  0.52915213
p_int:  0.979446207
p_ni:  0.020000177
p_wrong:  0.000553616
Score:  0.193
Data Source:  BioPlex,STRINGDB
MUT
Tbio
Family:  Enzyme
Novelty:  0.00074807
p_int:  0.968147111
p_ni:  0.031852889
Score:  0.623
Data Source:  BioPlex,STRINGDB
CFI
Tbio
Novelty:  0.00271423
Score:  0.999
Data Source:  Reactome,STRINGDB
C3
Tclin
Novelty:  0.00019115
Score:  0.999
Data Source:  Reactome,STRINGDB
CFHR1
Tbio
Novelty:  0.00676665
Score:  0.971
Data Source:  STRINGDB
CFHR2
Tbio
Novelty:  0.05323507
Score:  0.948
Data Source:  STRINGDB
CFB
Tchem
Novelty:  0.00102672
Score:  0.946
Data Source:  Reactome,STRINGDB
ARMS2
Tbio
Novelty:  0.00455168
Score:  0.922
Data Source:  STRINGDB
CRP
Tbio
Novelty:  0.00001517
Score:  0.869
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (170)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
17
0
2.4
100
4
9
0
2.4
99.8
blood protein measurement
107
16
106
1.4
99.8
atrophic macular degeneration
2
7
0
2.6
99.3
complement factor H measurement
4
5
4
4253
99.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.4
100
0
2.4
99.8
blood protein measurement
106
1.4
99.8
atrophic macular degeneration
0
2.6
99.3
complement factor H measurement
4
4253
99.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement factor H
VGNC:1214
457601
Mouse
MGI:88385
12628
Rat
RGD:620428
155012
Dog
complement factor H
478952
Horse
complement factor H
100051358
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement factor H
Mouse
Rat
Dog
complement factor H
Horse
complement factor H
Publication Statistics
PubMed Score 1979.64
PubMed score by year
PubTator Score 1744.96
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title