You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CFC1
Cryptic protein

Protein Summary
Description
NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation. This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259216
  • ENSP00000259216
  • ENSG00000136698

Symbol
  • HTX2
  • CFC1B
  • DTGA2
  • CRYPTIC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
PubMedID
0.54
phenotype
0.51
chemical
0.41
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.56   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.56   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
NODAL
Tbio
Novelty:  0.01033642
Score:  0.982
Data Source:  Reactome,STRINGDB
LEFTY2
Tbio
Novelty:  0.01038653
Score:  0.974
Data Source:  Reactome,STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
Score:  0.972
Data Source:  Reactome,STRINGDB
LEFTY1
Tbio
Novelty:  0.01608284
Score:  0.966
Data Source:  Reactome,STRINGDB
ACVR1B
Tchem
Family:  Kinase
Novelty:  0.00633595
Score:  0.949
Data Source:  Reactome,STRINGDB
ACVR2A
Tchem
Family:  Kinase
Novelty:  0.0063932
Score:  0.945
Data Source:  Reactome,STRINGDB
ACVR1C
Tbio
Family:  Kinase
Novelty:  0.01675672
Score:  0.936
Data Source:  Reactome,STRINGDB
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
Score:  0.933
Data Source:  STRINGDB
TDGF1
Tbio
Novelty:  0.00527099
Score:  0.919
Data Source:  Reactome,STRINGDB
CER1
Tbio
Novelty:  0.01834422
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of signaling by NODAL
Reactome
Signaling by NODAL
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of signaling by NODAL
Signaling by NODAL
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chicken
cripto, FRL-1, cryptic family 1
CGNC:49319
395437
Species
Name
OMA
EggNOG
Inparanoid
Chicken
cripto, FRL-1, cryptic family 1
Publication Statistics
PubMed Score 51.56
PubMed score by year
PubTator Score 934.01
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title