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Tdark
CFAP300
Cilia- and flagella-associated protein 300

Protein Summary
Description
Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000434758
  • ENSP00000414390
  • ENSG00000137691
  • ENST00000534360
  • ENSP00000435482

Symbol
  • C11orf70
  • CILD38
  • C11orf70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.37   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.37   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.971646573
p_ni:  0.028353423
p_wrong:  4e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.854741905
p_ni:  0.145258095
Score:  0.183
Data Source:  BioPlex,STRINGDB
CEP126
Tdark
Novelty:  0.25270575
Score:  0.768
Data Source:  STRINGDB
FNDC11
Tdark
Novelty:  20.00979352
Score:  0.537
Data Source:  STRINGDB
CFAP206
Tdark
Novelty:  1.22847252
Score:  0.529
Data Source:  STRINGDB
UBL4B
Tdark
Novelty:  0.56877836
Score:  0.52
Data Source:  STRINGDB
C2orf69
Tdark
Novelty:  1.58983924
Score:  0.518
Data Source:  STRINGDB
NAIF1
Tbio
Novelty:  0.1179429
Score:  0.506
Data Source:  STRINGDB
ZNF558
Tdark
Family:  TF
Novelty:  0.821338
Score:  0.493
Data Source:  STRINGDB
FSCN3
Tdark
Novelty:  0.28942634
Score:  0.492
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
1
1.2
71.9
migraine disorder
1
1
0
1
66.3
sex hormone-binding globulin measurement
3
1
2
5.9
44
pulse pressure measurement
1
1
1
36.4
calcium measurement
1
1
1
32.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
71.9
migraine disorder
0
1
66.3
sex hormone-binding globulin measurement
2
5.9
44
pulse pressure measurement
1
36.4
calcium measurement
1
32.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cilia and flagella associated protein 300
VGNC:3185
451505
Macaque
chromosome 14 open reading frame, human C11orf70
100425161
Mouse
MGI:3045346
234912
Rat
RGD:1591894
654482
Dog
cilia and flagella associated protein 300
VGNC:53318
611894
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cilia and flagella associated protein 300
Macaque
chromosome 14 open reading frame, human C11orf70
Mouse
Rat
Dog
cilia and flagella associated protein 300
Publication Statistics
PubMed Score 2.37
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title