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Tbio
CFAP20
Cilia- and flagella-associated protein 20

Protein Summary
Description
Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia (PubMed:24414207). Required for axonemal microtubules polyglutamylation (PubMed:24414207).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262498
  • ENSP00000262498
  • ENSG00000070761

Symbol
  • BUG22
  • C16orf80
  • GTL3
  • GTL3
  • BUG22
  • EVORF
  • fSAP23
  • C16orf80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
kinase perturbation
0.84
transcription factor
0.66
cellular component
0.64
cell type or tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.46   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.46   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
SFSWAP
Tdark
Novelty:  0.2236256
p_int:  0.999999976
p_ni:  2.4e-8
Score:  0.382
Data Source:  BioPlex,STRINGDB
TBC1D32
Tbio
Novelty:  0.25744084
p_int:  0.999999968
p_ni:  9e-9
p_wrong:  2.3e-8
Score:  0.852
Data Source:  BioPlex,STRINGDB
CDK20
Tbio
Family:  Kinase
Novelty:  0.01176977
p_int:  0.999999731
p_ni:  2.69e-7
Score:  0.513
Data Source:  BioPlex,STRINGDB
CLASRP
Tbio
Novelty:  0.00582947
p_int:  0.999995925
p_ni:  0.000004075
Score:  0.35
Data Source:  BioPlex,STRINGDB
RABEPK
Tdark
Novelty:  0.97019495
p_int:  0.999788697
p_ni:  0.000211303
Score:  0.241
Data Source:  BioPlex,STRINGDB
FAM149B1
Tdark
Novelty:  0.87415255
p_int:  0.991489326
p_ni:  0.008510674
Score:  0.869
Data Source:  BioPlex,STRINGDB
ARL2BP
Tbio
Novelty:  0.03460574
p_int:  0.985069614
p_ni:  0.014930385
p_wrong:  1e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
SPINDOC
Tdark
Novelty:  0.70981211
p_int:  0.982763213
p_ni:  0.017236787
Score:  0.187
Data Source:  BioPlex,STRINGDB
RSRC1
Tbio
Novelty:  0.12148079
p_int:  0.982386435
p_ni:  0.000892344
p_wrong:  0.016721222
Score:  0.179
Data Source:  BioPlex,STRINGDB
PNN
Tbio
Novelty:  0.01395394
p_int:  0.961590261
p_ni:  0.038409739
Score:  0.167
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
General transcription regulation
PathwayCommons: panther
Transcription regulation by bZIP transcription factor
Name
Explore in Pharos
Explore in Source
General transcription regulation
Transcription regulation by bZIP transcription factor
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
3
3
92.4
FEV/FEC ratio
1
1
1
82.1
serum alanine aminotransferase measurement
1
1
0
6.4
44.2
pulmonary function measurement
1
1
1
15.8
telomere length
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
92.4
FEV/FEC ratio
1
82.1
serum alanine aminotransferase measurement
0
6.4
44.2
pulmonary function measurement
1
15.8
telomere length
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cilia and flagella associated protein 20
VGNC:5732
454130
Macaque
cilia and flagella associated protein 20
706737
Mouse
MGI:107428
14894
Dog
cilia and flagella associated protein 20
VGNC:39159
487256
Horse
cilia and flagella associated protein 20
VGNC:16451
100052433
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cilia and flagella associated protein 20
Macaque
cilia and flagella associated protein 20
Mouse
Dog
cilia and flagella associated protein 20
Horse
cilia and flagella associated protein 20
Publication Statistics
PubMed Score 55.46
PubMed score by year
PubTator Score 26.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title