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Tchem
CETP
Cholesteryl ester transfer protein

Protein Summary
Description
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796). The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000200676
  • ENSP00000200676
  • ENSG00000087237
  • ENST00000379780
  • ENSP00000369106

Symbol
  • BPIFF
  • HDLCQ10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
biological term
0.99
disease
0.87
trait
0.86
molecular function
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2142.15   (req: < 5)
Gene RIFs: 409   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2142.15   (req: >= 5)
Gene RIFs: 409   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 846
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (99)
APOA1
Tbio
Novelty:  0.0001216
Score:  0.989
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.989
Data Source:  STRINGDB
APOF
Tbio
Novelty:  0.02636736
Score:  0.979
Data Source:  STRINGDB
LCAT
Tchem
Family:  Enzyme
Novelty:  0.00307544
Score:  0.972
Data Source:  STRINGDB
LPA
Tbio
Family:  Enzyme
Novelty:  0.00054858
Score:  0.96
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.942
Data Source:  STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.938
Data Source:  STRINGDB
APOC3
Tclin
Novelty:  0.0009635
Score:  0.938
Data Source:  STRINGDB
APOC1
Tbio
Novelty:  0.00338935
Score:  0.932
Data Source:  STRINGDB
LIPC
Tchem
Family:  Enzyme
Novelty:  0.00219107
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
HDL remodeling (R-HSA-8964058)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HDL remodeling
Reactome
LDL remodeling
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
HDL remodeling
LDL remodeling
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (55)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
53
77
186
2.7
100
apolipoprotein A 1 measurement
2
33
33
100
sleep duration
4
17
25
99.9
total cholesterol measurement
13
26
44
2.5
99.4
triglyceride measurement
17
20
42
2.9
99
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
186
2.7
100
apolipoprotein A 1 measurement
33
100
sleep duration
25
99.9
total cholesterol measurement
44
2.5
99.4
triglyceride measurement
42
2.9
99
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cholesteryl ester transfer protein
VGNC:9022
467982
Macaque
cholesteryl ester transfer protein
710267
Opossum
cholesteryl ester transfer protein
100021113
Platypus
cholesteryl ester transfer protein [Source:HGNC Symbol;Acc:HGNC:1869]
Chicken
cholesteryl ester transfer protein
CGNC:841
415645
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cholesteryl ester transfer protein
Macaque
cholesteryl ester transfer protein
Opossum
cholesteryl ester transfer protein
Platypus
cholesteryl ester transfer protein [Source:HGNC Symbol;Acc:HGNC:1869]
Chicken
cholesteryl ester transfer protein
Publication Statistics
PubMed Score 2142.15
PubMed score by year
PubTator Score 1568.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title