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Tbio
CETN3
Centrin-3

Protein Summary
Description
Plays a fundamental role in microtubule-organizing center structure and function. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388). The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have be ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283122
  • ENSP00000283122
  • ENSG00000153140

Symbol
  • CEN3
  • CEN3
  • CDC31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.91
transcription factor binding site profile
0.82
tissue sample
0.73
cell type or tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.92   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.92   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
XPC
Tbio
Novelty:  0.00775175
p_int:  0.999737675
p_ni:  0.000262325
Score:  0.799
Data Source:  BioPlex,STRINGDB
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.999049939
p_ni:  0.000950061
Score:  0.571
Data Source:  BioPlex,STRINGDB
PNOC
Tbio
Novelty:  0.00132014
p_int:  0.998095252
p_ni:  0.001904748
Data Source:  BioPlex
POC5
Tbio
Novelty:  0.09211907
p_int:  0.995446517
p_ni:  0.004553483
Score:  0.873
Data Source:  BioPlex,STRINGDB
GRP
Tbio
Novelty:  0.00034247
p_int:  0.994634802
p_ni:  0.005364653
p_wrong:  5.45e-7
Data Source:  BioPlex
MYO19
Tbio
Novelty:  0.13070371
p_int:  0.992968469
p_ni:  0.007031522
p_wrong:  9e-9
Score:  0.232
Data Source:  BioPlex,STRINGDB
TCAP
Tbio
Novelty:  0.00623581
p_int:  0.985426821
p_ni:  0.014564392
p_wrong:  0.000008787
Score:  0.241
Data Source:  BioPlex,STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
p_int:  0.980116139
p_ni:  0.019883855
p_wrong:  6e-9
Score:  0.244
Data Source:  BioPlex,STRINGDB
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
p_int:  0.975857512
p_ni:  0.024142488
Data Source:  BioPlex
BCKDK
Tbio
Family:  Kinase
Novelty:  0.03296998
p_int:  0.957902366
p_ni:  0.042097629
p_wrong:  5e-9
Score:  0.591
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (443)
Find Similar Targets
Items per page:
1 – 5 of 443
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Breast cancer pathway
WikiPathways
Breast cancer pathway
WikiPathways
Breast cancer pathway
WikiPathways
Breast cancer pathway
WikiPathways
Breast cancer pathway
Name
Explore in Pharos
Explore in Source
Breast cancer pathway
Breast cancer pathway
Breast cancer pathway
Breast cancer pathway
Breast cancer pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrin 3
VGNC:3949
738363
Macaque
centrin 3
695223
Mouse
MGI:1097706
12626
Rat
RGD:620249
170895
Rat
RGD:6486167
100912538
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrin 3
Macaque
centrin 3
Mouse
Rat
Rat
Publication Statistics
PubMed Score 139.92
PubMed score by year
PubTator Score 21.85
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title