Tbio CETN3 Centrin-3

Protein Summary

Description

Plays a fundamental role in microtubule-organizing center structure and function. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388). The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• O15182
• Q53YD2
• Q9BS23

Gene Name

• CETN3

Ensembl ID

• ENST00000283122
• ENSP00000283122
• ENSG00000153140

Symbol

• CEN3
• CEN3
• CDC31

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
kinase perturbation	0.91
transcription factor binding site profile	0.82
tissue sample	0.73
cell type or tissue	0.67

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Centrin-3

DTO Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Centrin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.92   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.92   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (148)

Explore Interacting Targets

1 – 10 of 148

• See Interactions on String-DB

XPC

Tbio

Novelty:  0.00775175

p_int:  0.999737675

p_ni:  0.000262325

Score:  0.799

Data Source:  BioPlex,STRINGDB

CETN1

Tbio

Novelty:  0.01208917

p_int:  0.999049939

p_ni:  0.000950061

Score:  0.571

Data Source:  BioPlex,STRINGDB

PNOC

Tbio

Novelty:  0.00132014

p_int:  0.998095252

p_ni:  0.001904748

Data Source:  BioPlex

POC5

Tbio

Novelty:  0.09211907

p_int:  0.995446517

p_ni:  0.004553483

Score:  0.873

Data Source:  BioPlex,STRINGDB

GRP

Tbio

Novelty:  0.00034247

p_int:  0.994634802

p_ni:  0.005364653

p_wrong:  5.45e-7

Data Source:  BioPlex

MYO19

Tbio

Novelty:  0.13070371

p_int:  0.992968469

p_ni:  0.007031522

p_wrong:  9e-9

Score:  0.232

Data Source:  BioPlex,STRINGDB

TCAP

Tbio

Novelty:  0.00623581

p_int:  0.985426821

p_ni:  0.014564392

p_wrong:  0.000008787

Score:  0.241

Data Source:  BioPlex,STRINGDB

RHOD

Tbio

Family:  Enzyme

Novelty:  0.0029764

p_int:  0.980116139

p_ni:  0.019883855

p_wrong:  6e-9

Score:  0.244

Data Source:  BioPlex,STRINGDB

DMAP1

Tbio

Family:  Enzyme

Novelty:  0.03152166

p_int:  0.975857512

p_ni:  0.024142488

Data Source:  BioPlex

BCKDK

Tbio

Family:  Kinase

Novelty:  0.03296998

p_int:  0.957902366

p_ni:  0.042097629

p_wrong:  5e-9

Score:  0.591

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (443)

WikiPathways (443)

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5

1 – 5 of 443

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Breast cancer pathway	2555 targets	WP4262_r105490
WikiPathways	Breast cancer pathway	2555 targets	WP4262_r105490
WikiPathways	Breast cancer pathway	2555 targets	WP4262_r105490
WikiPathways	Breast cancer pathway	2555 targets	WP4262_r105490
WikiPathways	Breast cancer pathway	2555 targets	WP4262_r105490

Name	Explore in Pharos	Explore in Source
Breast cancer pathway	2555 targets	WP4262_r105490
Breast cancer pathway	2555 targets	WP4262_r105490
Breast cancer pathway	2555 targets	WP4262_r105490
Breast cancer pathway	2555 targets	WP4262_r105490
Breast cancer pathway	2555 targets	WP4262_r105490

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (2)

Components (6)

Processes (6)

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1 – 2 of 2

GO Term	Evidence	Assigned by
microtubule binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Calcium
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Metal-binding
Mitosis
Nucleus
Phosphoprotein

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	centrin 3	VGNC:3949	738363
Macaque	centrin 3		695223
Mouse	centrin 3	MGI:1097706	12626
Rat	centrin 3	RGD:620249	170895
Rat	centrin-3-like	RGD:6486167	100912538

Species	Name	OMA	EggNOG	Inparanoid
Chimp	centrin 3
Macaque	centrin 3
Mouse	centrin 3
Rat	centrin 3
Rat	centrin-3-like

Publication Statistics

PubMed Score 139.92

PubMed score by year

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PubTator Score 21.85

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (4)

Items per page:

10

0 of 0

PMID	Year	Title