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Tbio
CES4A
Carboxylesterase 4A

Protein Summary
Description
Probable carboxylesterase. This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000535696
  • ENSP00000441644
  • ENSG00000172824
  • ENST00000540579
  • ENSP00000441907
  • ENST00000540947
  • ENSP00000444052

Symbol
  • CES8
  • CES6
  • CES8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.6
protein domain
0.58
tissue
0.49
cell type or tissue
0.43
disease perturbation
0.43


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
LRAT
Tbio
Family:  Enzyme
Novelty:  0.00593203
Score:  0.917
Data Source:  STRINGDB
RBP4
Tchem
Novelty:  0.00168442
Score:  0.905
Data Source:  STRINGDB
SPANXC
Tbio
Novelty:  0.14907666
Score:  0.748
Data Source:  STRINGDB
HPGDS
Tchem
Family:  Enzyme
Novelty:  0.00019629
Score:  0.672
Data Source:  STRINGDB
TOP1
Tclin
Family:  Enzyme
Novelty:  0.00019573
Score:  0.649
Data Source:  STRINGDB
ASGR1
Tbio
Novelty:  0.00209845
Score:  0.648
Data Source:  STRINGDB
UGT1A9
Tbio
Family:  Enzyme
Novelty:  0.0047848
Score:  0.641
Data Source:  STRINGDB
UGT1A6
Tbio
Family:  Enzyme
Novelty:  0.00146917
Score:  0.623
Data Source:  STRINGDB
UGT1A8
Tbio
Family:  Enzyme
Novelty:  0.00135129
Score:  0.622
Data Source:  STRINGDB
AADAC
Tchem
Family:  Enzyme
Novelty:  0.02735072
Score:  0.615
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
80.6
apolipoprotein A 1 measurement
1
2
2
70.2
high density lipoprotein cholesterol measurement
1
2
2
66.6
blood protein measurement
1
1
1
58.4
monocyte count
1
1
1
24.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
80.6
apolipoprotein A 1 measurement
2
70.2
high density lipoprotein cholesterol measurement
2
66.6
blood protein measurement
1
58.4
monocyte count
1
24.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2384581
234677
Rat
RGD:1307418
291955
Cow
carboxylesterase 4A
VGNC:27231
529706
Opossum
carboxylesterase 4A
100019639
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
carboxylesterase 4A
Opossum
carboxylesterase 4A
Publication Statistics
PubMed Score 6.19
PubMed score by year
PubTator Score 3.11
PubTator score by year
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Related Publications
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PMID
Year
Title