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Tbio
CERS5
Ceramide synthase 5

Protein Summary
Description
Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity). This gene encodes a protein that belongs to the TLC (TRAM, LAG1 and CLN8 homology domains) family of proteins. The encoded protein functions in the synthesis of ceramide, a lipid molecule that is involved in a several cellular signaling pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317551
  • ENSP00000325485
  • ENSG00000139624
  • ENST00000422340
  • ENSP00000389050

Symbol
  • LASS5
  • Trh4
  • LASS5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
kinase perturbation
0.76
tissue sample
0.7
cellular component
0.69
cell line
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.29   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.29   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.999916106
p_ni:  0.000083873
p_wrong:  2.1e-8
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.999743107
p_ni:  0.000256892
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.999544167
p_ni:  0.000065122
p_wrong:  0.000390711
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.9992879
p_ni:  0.000701075
p_wrong:  0.000011025
Data Source:  BioPlex
HCAR1
Tchem
Family:  GPCR
Novelty:  0.01809094
p_int:  0.997919549
p_ni:  0.001626195
p_wrong:  0.000454256
Data Source:  BioPlex
CD83
Tbio
Novelty:  0.00138653
p_int:  0.997310188
p_ni:  0.002578672
p_wrong:  0.000111139
Data Source:  BioPlex
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.997188815
p_ni:  0.002811011
p_wrong:  1.75e-7
Score:  0.159
Data Source:  BioPlex,STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.995806976
p_ni:  0.004192974
p_wrong:  5e-8
Data Source:  BioPlex
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.99544019
p_ni:  0.00455969
p_wrong:  1.21e-7
Data Source:  BioPlex
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.994517396
p_ni:  0.000446121
p_wrong:  0.005036483
Data Source:  BioPlex
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
75.1
neutrophil count
1
1
1
71.5
diastolic blood pressure
1
1
1
70.8
low density lipoprotein cholesterol measurement
2
1
2
68
apolipoprotein B measurement
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
75.1
neutrophil count
1
71.5
diastolic blood pressure
1
70.8
low density lipoprotein cholesterol measurement
2
68
apolipoprotein B measurement
1
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ceramide synthase 5
VGNC:5336
451891
Macaque
ceramide synthase 5
713449
Mouse
MGI:1919199
71949
Rat
RGD:1311597
366984
Dog
ceramide synthase 5
VGNC:39151
477611
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ceramide synthase 5
Macaque
ceramide synthase 5
Mouse
Rat
Dog
ceramide synthase 5
Publication Statistics
PubMed Score 36.29
PubMed score by year
PubTator Score 24.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title