CERS2
Ceramide synthase 2
Protein Summary
Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis. This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
- ENST00000271688
- ENSP00000271688
- ENSG00000143418
- ENST00000368954
- ENSP00000357950
- LASS2
- TMSG1
- L3
- LASS2
- SP260
- TMSG1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.98 | ||
cellular component | 0.79 | ||
transcription factor perturbation | 0.74 | ||
microRNA | 0.69 | ||
PubMedID | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 153.17 (req: < 5)
Gene RIFs: 50 (req: <= 3)
Antibodies: 197 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 153.17 (req: >= 5)
Gene RIFs: 50 (req: > 3)
Antibodies: 197 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0