Tbio CERS2 Ceramide synthase 2

Protein Summary

Description

Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis. This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96G23
• D3DV06
• Q5SZE5
• Q9HD96
• Q9NW79
• CerS2

Gene Name

• CERS2

Ensembl ID

• ENST00000271688
• ENSP00000271688
• ENSG00000143418
• ENST00000368954
• ENSP00000357950

Symbol

• LASS2
• TMSG1
• L3
• LASS2
• SP260
• TMSG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
cellular component	0.79
transcription factor perturbation	0.74
microRNA	0.69
PubMedID	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.65   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.65   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (82)

Explore Interacting Targets

1 – 10 of 82

• See Interactions on String-DB

ATP5F1B

Tbio

Family:  Enzyme

Novelty:  0.01053177

p_int:  0.963736482

p_ni:  0.036263518

Score:  0.75

Data Source:  BioPlex,STRINGDB

POMK

Tbio

Family:  Kinase

Novelty:  0.09340344

p_int:  0.954695225

p_ni:  0.045304775

Score:  0.524

Data Source:  BioPlex,STRINGDB

VIPR2

Tchem

Family:  GPCR

Novelty:  0.00463802

p_int:  0.949799788

p_ni:  0.050200212

Data Source:  BioPlex

HTR2C

Tclin

Family:  GPCR

Novelty:  0.00074287

p_int:  0.932710777

p_ni:  0.067289223

Data Source:  BioPlex

TACR1

Tclin

Family:  GPCR

Novelty:  0.00062762

p_int:  0.923281813

p_ni:  0.076718187

Score:  0.307

Data Source:  BioPlex,STRINGDB

C3AR1

Tchem

Family:  GPCR

Novelty:  0.00527301

p_int:  0.916112659

p_ni:  0.083887341

Score:  0.313

Data Source:  BioPlex,STRINGDB

TNFSF18

Tbio

Novelty:  0.01423949

p_int:  0.898108317

p_ni:  0.101891683

Data Source:  BioPlex

ATP5PB

Tbio

Family:  Enzyme

Novelty:  0.07345384

p_int:  0.875002399

p_ni:  0.124997601

Score:  0.686

Data Source:  BioPlex,STRINGDB

RELL1

Tbio

Novelty:  0.28949625

p_int:  0.867483228

p_ni:  0.132516772

Score:  0.588

Data Source:  BioPlex,STRINGDB

LPAR1

Tchem

Family:  GPCR

Novelty:  0.00318056

p_int:  0.845188527

p_ni:  0.154811473

Score:  0.345

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (1)

1 – 1 of 1

UGCG

Tclin

Family:  Enzyme

KEGG Distance:  3

Common Pathways:  2

1: Metabolic pathways

2: Sphingolipid metabolism

Pathways (8)

Reactome (4)

KEGG (3)

WikiPathways (1)

Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Sphingolipid de novo biosynthesis	44 targets	R-HSA-1660661
Reactome	Sphingolipid metabolism	90 targets	R-HSA-428157

Name	Explore in Pharos	Explore in Source
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Sphingolipid de novo biosynthesis	44 targets	R-HSA-1660661
Sphingolipid metabolism	90 targets	R-HSA-428157

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (2)

Components (5)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
sphingosine N-acyltransferase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (39)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 39

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	8	5	8	9.2	97.1
apolipoprotein A 1 measurement	EFO_0004614	2	3	3		95.6
sex hormone-binding globulin measurement	EFO_0004696	6	2	6		89.7
creatinine measurement	EFO_0004518	4	4	5		88.9
high density lipoprotein cholesterol measurement	EFO_0004612	3	2	3		85

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 39

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	8	9.2	97.1
apolipoprotein A 1 measurement	EFO_0004614	3		95.6
sex hormone-binding globulin measurement	EFO_0004696	6		89.7
creatinine measurement	EFO_0004518	5		88.9
high density lipoprotein cholesterol measurement	EFO_0004612	3		85

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
DNA-binding
Endoplasmic reticulum
Glycoprotein
Homeobox
Lipid biosynthesis
Lipid metabolism
Membrane
Nucleus
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
apolipoprotein B measurement
aspartate aminotransferase measurement
attention deficit hyperactivity disorder
bitter non-alcoholic beverage consumption measurement
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
body height
body mass index
calcium measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype
liver/biliary system phenotype
neoplasm
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ceramide synthase 2	VGNC:495	469482
Macaque	ceramide synthase 2		716180
Mouse	ceramide synthase 2	MGI:1924143	76893
Rat	ceramide synthase 2	RGD:1310059	310667
Dog	ceramide synthase 2	VGNC:39148	483187

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ceramide synthase 2
Macaque	ceramide synthase 2
Mouse	ceramide synthase 2
Rat	ceramide synthase 2
Dog	ceramide synthase 2

Publication Statistics

PubMed Score 130.65

PubMed score by year

Reset Zoom

PubTator Score 53.63

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (46)

GeneRif Annotations (30)

Items per page:

10

0 of 0

PMID	Year	Title