Tchem CERK Ceramide kinase

Protein Summary

Description

Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q8TCT0
• A0JNT4
• A8K611
• Q6NX59
• Q9BYB3
• Q9UGE5
• hCERK

Gene Name

• CERK

Ensembl ID

• ENST00000216264
• ENSP00000216264
• ENSG00000100422

Symbol

• KIAA1646
• LK4
• hCERK
• dA59H18.2
• dA59H18.3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
molecular function	0.96
virus perturbation	0.95
transcription factor perturbation	0.91
transcription factor binding site profile	0.74

Protein Classes

DTO Classes

Protein / Kinase / Non-protein Kinase / Lipid Kinase / Ceramide Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.56   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 293   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.56   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

NVP 231

CERKTchem Kinase

-log(-) : 7.9

Protein-Protein Interactions (90)

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1 – 10 of 90

• See Interactions on String-DB

PDCD2

Tbio

Novelty:  0.05054811

p_int:  0.999973464

p_ni:  0.000026524

p_wrong:  1.2e-8

Data Source:  BioPlex

GMNN

Tbio

Novelty:  0.00436572

p_int:  0.999607641

p_ni:  0.00039235

p_wrong:  9e-9

Data Source:  BioPlex

KCTD17

Tbio

Novelty:  0.12105733

p_int:  0.999491937

p_ni:  0.000508063

Score:  0.153

Data Source:  BioPlex,STRINGDB

CCNDBP1

Tbio

Novelty:  0.01527762

p_int:  0.999392091

p_ni:  0.000605688

p_wrong:  0.000002221

Score:  0.177

Data Source:  BioPlex,STRINGDB

TNFRSF9

Tbio

Novelty:  0.00162382

p_int:  0.996073064

p_ni:  0.003814281

p_wrong:  0.000112655

Score:  0.261

Data Source:  BioPlex,STRINGDB

VWCE

Tbio

Novelty:  0.09328341

p_int:  0.993913181

p_ni:  0.005564123

p_wrong:  0.000522696

Data Source:  BioPlex

HEPACAM2

Tbio

Novelty:  0.19192547

p_int:  0.992706426

p_ni:  0.006073343

p_wrong:  0.001220231

Data Source:  BioPlex

HAVCR2

Tbio

Novelty:  0.00155885

p_int:  0.989670341

p_ni:  0.010307763

p_wrong:  0.000021896

Data Source:  BioPlex

CD83

Tbio

Novelty:  0.00138653

p_int:  0.975386702

p_ni:  0.023241376

p_wrong:  0.001371922

Data Source:  BioPlex

TPCN2

Tchem

Family:  IC

Novelty:  0.01351129

p_int:  0.969441356

p_ni:  0.026782971

p_wrong:  0.003775674

Data Source:  BioPlex

Nearest Tclin Targets (2)

Explore Nearest Tclin Targets

Upstream (1)

Downstream (1)

1 – 1 of 1

UGCG

Tclin

Family:  Enzyme

KEGG Distance:  3

Common Pathways:  1

1: Sphingolipid metabolism

Pathways (62)

Reactome (4)

KEGG (1)

WikiPathways (57)

Glycosphingolipid metabolism (R-HSA-1660662)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Sphingolipid metabolism	90 targets	R-HSA-428157

Name	Explore in Pharos	Explore in Source
Glycosphingolipid metabolism	46 targets	R-HSA-1660662
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Sphingolipid metabolism	90 targets	R-HSA-428157

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (5)

Components (3)

Processes (2)

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1 – 5 of 5

GO Term	Evidence	Assigned by
ceramide kinase activity	Inferred from Direct Assay (IDA)	UniProtKB
magnesium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
dihydroceramide kinase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
NAD+ kinase activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	1	1	1		50.6
cortical thickness	EFO_0004840	1	1	1		49.5
BMI-adjusted waist-hip ratio	EFO_0007788	1	1	1		35

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	1		50.6
cortical thickness	EFO_0004840	1		49.5
BMI-adjusted waist-hip ratio	EFO_0007788	1		35

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
ATP-binding
Calcium
Complete proteome
Cytoplasm
Kinase
Magnesium
Membrane
Nucleotide-binding
Phosphoprotein

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist-hip ratio
cortical thickness
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
digestive/alimentary phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ceramide kinase	VGNC:5975	458921
Macaque	ceramide kinase		714480
Mouse	ceramide kinase	MGI:2386052	223753
Rat	ceramide kinase	RGD:1305019	300129
Dog	ceramide kinase	VGNC:54519	474464

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ceramide kinase
Macaque	ceramide kinase
Mouse	ceramide kinase
Rat	ceramide kinase
Dog	ceramide kinase

Publication Statistics

PubMed Score 111.56

PubMed score by year

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PubTator Score 46.41

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Patents

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Related Publications

Text Mined References (32)

GeneRif Annotations (21)

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PMID	Year	Title