Tbio CER1 Cerberus

Protein Summary

Description

Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity). This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95813
• Q6ISJ1
• Q6ISJ6
• Q6ISQ2
• Q6ISS1

Gene Name

• CER1

Ensembl ID

• ENST00000380911
• ENSP00000370297
• ENSG00000147869

Symbol

• DAND4
• DAND4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.76
gene perturbation	0.62
cell type or tissue	0.58
cell line	0.56
tissue	0.42

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.52   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.52   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0