Protein Summary
Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity). This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]
- ENST00000380911
- ENSP00000370297
- ENSG00000147869
- DAND4
- DAND4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.76 | ||
gene perturbation | 0.62 | ||
cell type or tissue | 0.58 | ||
cell line | 0.56 | ||
tissue | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.02 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 232 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.02 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 232 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (67)
HSPA1A
Novelty: 0.00069195
p_int: 0.999527792
p_ni: 0.000472207
Score: 0.234
Data Source: BioPlex,STRINGDB
FN1
Novelty: 0.00003647
p_int: 0.998167273
p_ni: 0.001832727
Score: 0.345
Data Source: BioPlex,STRINGDB
PPM1A
Family: Enzyme
Novelty: 0.01464968
p_int: 0.99397269
p_ni: 0.006027285
p_wrong: 2.6e-8
Score: 0.177
Data Source: BioPlex,STRINGDB
VHL
Family: Enzyme
Novelty: 0.00285782
p_int: 0.930887324
p_ni: 0.068328229
p_wrong: 0.000784446
Score: 0.177
Data Source: BioPlex,STRINGDB
POTEF
Novelty: 0.00191599
p_int: 0.849141307
p_ni: 0.150858693
Score: 0.15
Data Source: BioPlex,STRINGDB
MRC2
Novelty: 0.01100289
p_int: 0.803831624
p_ni: 0.196066782
p_wrong: 0.000101595
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (94)
Reactome (6)
KEGG (1)
PathwayCommons (2)
WikiPathways (85)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Developmental Biology | ||||
Reactome | Regulation of signaling by NODAL | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by BMP | ||||
Reactome | Signaling by NODAL | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Developmental Biology | ||||
Regulation of signaling by NODAL | ||||
Signal Transduction | ||||
Signaling by BMP | ||||
Signaling by NODAL | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (4)
Components (2)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 1 | 2 | 2 | 59.4 | |||||
lifestyle measurement | 1 | 1 | 1 | 26.6 | |||||
age at first birth measurement | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 2 | 59.4 | |||||
lifestyle measurement | 1 | 26.6 | |||||
age at first birth measurement | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cerberus 1, DAN family BMP antagonist | VGNC:13892 | 473172 | |||||
Macaque | cerberus 1, DAN family BMP antagonist | 713924 | ||||||
Mouse | MGI:1201414 | 12622 | ||||||
Rat | RGD:1563046 | 500485 | ||||||
Dog | cerberus 1, DAN family BMP antagonist | VGNC:39145 | 611037 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cerberus 1, DAN family BMP antagonist | |||||
Macaque | cerberus 1, DAN family BMP antagonist | |||||
Mouse | ||||||
Rat | ||||||
Dog | cerberus 1, DAN family BMP antagonist | |||||
Publication Statistics
PubMed Score 51.02
PubMed score by year
PubTator Score 47.75
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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