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Tbio
CER1
Cerberus

Protein Summary
Description
Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity). This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380911
  • ENSP00000370297
  • ENSG00000147869

Symbol
  • DAND4
  • DAND4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
gene perturbation
0.62
cell type or tissue
0.58
cell line
0.56
tissue
0.42


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.02   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.02   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
HSPA1A
Tchem
Novelty:  0.00069195
p_int:  0.999527792
p_ni:  0.000472207
Score:  0.234
Data Source:  BioPlex,STRINGDB
FN1
Tchem
Novelty:  0.00003647
p_int:  0.998167273
p_ni:  0.001832727
Score:  0.345
Data Source:  BioPlex,STRINGDB
KLHL15
Tbio
Novelty:  0.54712519
p_int:  0.997810553
p_ni:  0.002189447
Data Source:  BioPlex
PPM1A
Tchem
Family:  Enzyme
Novelty:  0.01464968
p_int:  0.99397269
p_ni:  0.006027285
p_wrong:  2.6e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
VHL
Tchem
Family:  Enzyme
Novelty:  0.00285782
p_int:  0.930887324
p_ni:  0.068328229
p_wrong:  0.000784446
Score:  0.177
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.849141307
p_ni:  0.150858693
Score:  0.15
Data Source:  BioPlex,STRINGDB
MRC2
Tbio
Novelty:  0.01100289
p_int:  0.803831624
p_ni:  0.196066782
p_wrong:  0.000101595
Score:  0.189
Data Source:  BioPlex,STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.965
Data Source:  STRINGDB
NODAL
Tbio
Novelty:  0.01033642
Score:  0.964
Data Source:  Reactome,STRINGDB
BMP2
Tbio
Novelty:  0.00016974
Score:  0.956
Data Source:  STRINGDB
Pathways (94)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of signaling by NODAL
Reactome
Signal Transduction
Reactome
Signaling by BMP
Reactome
Signaling by NODAL
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of signaling by NODAL
Signal Transduction
Signaling by BMP
Signaling by NODAL
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
2
2
59.4
lifestyle measurement
1
1
1
26.6
age at first birth measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
59.4
lifestyle measurement
1
26.6
age at first birth measurement
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cerberus 1, DAN family BMP antagonist
VGNC:13892
473172
Macaque
cerberus 1, DAN family BMP antagonist
713924
Mouse
MGI:1201414
12622
Rat
RGD:1563046
500485
Dog
cerberus 1, DAN family BMP antagonist
VGNC:39145
611037
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cerberus 1, DAN family BMP antagonist
Macaque
cerberus 1, DAN family BMP antagonist
Mouse
Rat
Dog
cerberus 1, DAN family BMP antagonist
Publication Statistics
PubMed Score 51.02
PubMed score by year
PubTator Score 47.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title